The pleiotropic functions of reactive oxygen species in cancer
K Wu, AE El Zowalaty, VI Sayin… - Nature Cancer, 2024 - nature.com
Cellular redox homeostasis is an essential, dynamic process that ensures the balance
between reducing and oxidizing reactions within cells and thus has implications across all …
between reducing and oxidizing reactions within cells and thus has implications across all …
The relationship of redox with hallmarks of cancer: the importance of homeostasis and context
F Xing, Q Hu, Y Qin, J Xu, B Zhang, X Yu… - Frontiers in …, 2022 - frontiersin.org
Redox homeostasis is a lifelong pursuit of cancer cells. Depending on the context, reactive
oxygen species (ROS) exert paradoxical effects on cancers; an appropriate concentration …
oxygen species (ROS) exert paradoxical effects on cancers; an appropriate concentration …
Reactive oxygen species in cancer: a dance with the devil
PT Schumacker - Cancer cell, 2015 - cell.com
Reactive oxygen species (ROS) can initiate cancer, but oxidant generation in tumors leaves
them vulnerable to further stresses. In this issue of Cancer Cell, Harris and colleagues show …
them vulnerable to further stresses. In this issue of Cancer Cell, Harris and colleagues show …
The hallmarks of cancer from a redox perspective
M Hornsveld, TB Dansen - Antioxidants & redox signaling, 2016 - liebertpub.com
Significance: For a healthy cell to turn into a cancer cell and grow out to become a tumor, it
needs to undergo a series of complex changes and acquire certain traits, summarized as …
needs to undergo a series of complex changes and acquire certain traits, summarized as …
ROS in cancer: the burning question
IIC Chio, DA Tuveson - Trends in molecular medicine, 2017 - cell.com
An unanswered question in human health is whether antioxidation prevents or promotes
cancer. Antioxidation has historically been viewed as chemopreventive, but emerging …
cancer. Antioxidation has historically been viewed as chemopreventive, but emerging …
Inflammation, DAMPs, tumor development, and progression: a vicious circle orchestrated by redox signaling
P Castellani, E Balza, A Rubartelli - Antioxidants & redox signaling, 2014 - liebertpub.com
Significance: Increasing evidence indicates that cancer development and progression are
promoted by the joint action of redox distress and inflammation, supporting the potential …
promoted by the joint action of redox distress and inflammation, supporting the potential …
Reactive oxygen species-dependent signaling regulates cancer
F Weinberg, NS Chandel - Cellular and molecular life sciences, 2009 - Springer
Historically, it has been assumed that oxidative stress contributes to tumor initiation and
progression solely by inducing genomic instability. Recent studies indicate that reactive …
progression solely by inducing genomic instability. Recent studies indicate that reactive …
Redox homeostasis and cellular antioxidant systems: crucial players in cancer growth and therapy
B Marengo, M Nitti, AL Furfaro, R Colla… - Oxidative medicine …, 2016 - Wiley Online Library
Reactive oxygen species (ROS) and their products are components of cell signaling
pathways and play important roles in cellular physiology and pathophysiology. Under …
pathways and play important roles in cellular physiology and pathophysiology. Under …
Reductive stress, bioactive compounds, redox-active metals, and dormant tumor cell biology to develop redox-based tools for the treatment of cancer
JL Quiles, C Sánchez-González… - Antioxidants & Redox …, 2020 - liebertpub.com
Significance: Cancer is related to redox biology from many points of view, such as initiation
and promotion, metabolism and growth, invasion and metastasis, vascularization, or through …
and promotion, metabolism and growth, invasion and metastasis, vascularization, or through …
Reactive oxygen species in cancer cells: live by the sword, die by the sword
PT Schumacker - Cancer cell, 2006 - cell.com
Reactive oxygen species and tumor biology are intertwined in a complex web, making it
difficult to understand which came first, whether oxidants are required for tumor cell growth …
difficult to understand which came first, whether oxidants are required for tumor cell growth …