Reactive oxygen species in cancer biology and anticancer therapy

Y Yang, S Karakhanova, J Werner… - Current medicinal …, 2013 - ingentaconnect.com
Reactive oxygen species (ROS) are a group of highly reactive chemicals under tight control
of intracellular antioxidants. The balance in oxidation-antioxidation is essential for …

Reactive oxygen species bridge the gap between chronic inflammation and tumor development

W Yu, Y Tu, Z Long, J Liu, D Kong… - Oxidative medicine …, 2022 - Wiley Online Library
According to numerous animal studies, adverse environmental stimuli, including physical,
chemical, and biological factors, can cause low‐grade chronic inflammation and subsequent …

Oxidative stress, redox signaling and cancer chemoresistance: putting together the pieces of the puzzle

V Jacob Victorino, L Pizzatti… - Current medicinal …, 2014 - ingentaconnect.com
Chemotherapy continues to be the main treatment option for cancer. Although systemic
chemotherapy can efficiently eradicate cancer cells, a significant proportion of patients carry …

ROS homeostasis and metabolism: a critical liaison for cancer therapy

J Kim, J Kim, JS Bae - Experimental & molecular medicine, 2016 - nature.com
Evidence indicates that hypoxia and oxidative stress can control metabolic reprogramming
of cancer cells and other cells in tumor microenvironments and that the reprogrammed …

Small-molecule redox modulators with anticancer activity: A comprehensive mechanistic update

C Pal - Free Radical Biology and Medicine, 2023 - Elsevier
The pursuit of effective anticancer therapies has led to a burgeoning interest in the realm of
redox modulation. This review provides a comprehensive exploration of the intricate …

Oxidative stress in cancer

P Storz - Oxidative stress and redox regulation, 2013 - Springer
Increased oxidative stress is a common feature observed in many different types of cancer.
Depending on the radical formed, its concentration, and cellular location where its …

[HTML][HTML] The redox biology network in cancer pathophysiology and therapeutics

G Manda, G Isvoranu, MV Comanescu, A Manea… - Redox biology, 2015 - Elsevier
The review pinpoints operational concepts related to the redox biology network applied to
the pathophysiology and therapeutics of solid tumors. A sophisticated network of intrinsic …

[HTML][HTML] The interplay between reactive oxygen species and antioxidants in cancer progression and therapy: a narrative review

OH Bekhet, ME Eid - Translational Cancer Research, 2021 - ncbi.nlm.nih.gov
Objective To unveil the role of reactive oxygen species (ROS) and antioxidants in signaling
and involvement in cancer progression and therapy. Background Cancer is considered one …

Modulation of redox homeostasis: A strategy to overcome cancer drug resistance

Y Li, X Zhang, Z Wang, B Li, H Zhu - Frontiers in Pharmacology, 2023 - frontiersin.org
Cancer treatment is hampered by resistance to conventional therapeutic strategies,
including chemotherapy, immunotherapy, and targeted therapy. Redox homeostasis …

The cell cycle is a redox cycle: linking phase-specific targets to cell fate

WC Burhans, NH Heintz - Free Radical Biology and Medicine, 2009 - Elsevier
Reactive oxygen species (ROS) regulate the strength and duration of signaling through
redox-dependent signal transduction pathways via the cyclic oxidation/reduction of cysteine …