Mechanistic insight on the remdesivir binding to RNA-Dependent RNA polymerase (RdRp) of SARS-cov-2
The RNA-dependent RNA polymerase (RdRp) is a key enzyme which regulates the viral
replication of SARS-CoV-2. Remdesivir (RDV) is clinically used drug which targets RdRp …
replication of SARS-CoV-2. Remdesivir (RDV) is clinically used drug which targets RdRp …
Remdesivir MD simulations suggest a more favourable binding to SARS-CoV-2 RNA dependent RNA polymerase mutant P323L than wild-type
SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) protein is the target for the antiviral
drug Remdesivir (RDV). With RDV clinical trials on COVID-19 patients showing a reduced …
drug Remdesivir (RDV). With RDV clinical trials on COVID-19 patients showing a reduced …
RNA dependent RNA polymerase (RdRp) as a drug target for SARS-CoV2
A Mishra, AS Rathore - Journal of Biomolecular Structure and …, 2022 - Taylor & Francis
RNA-dependent RNA polymerase (RdRp), also called nsp12, is considered a promising but
challenging drug target for inhibiting replication and hence, the growth of various RNA …
challenging drug target for inhibiting replication and hence, the growth of various RNA …
Remdesivir strongly binds to RNA-dependent RNA polymerase, membrane protein, and main protease of SARS-CoV-2: indication from molecular modeling and …
Development of new drugs is a time-taking and expensive process. Comprehensive efforts
are being made globally toward the search of therapeutics against SARS-CoV-2. Several …
are being made globally toward the search of therapeutics against SARS-CoV-2. Several …
Remdesivir strongly binds to both RNA-dependent RNA polymerase and main protease of SARS-CoV-2: Evidence from molecular simulations
The outbreak of a new coronavirus SARS-CoV-2 (severe acute respiratory syndrome–
coronavirus 2) has caused a global COVID-19 (coronavirus disease 2019) pandemic …
coronavirus 2) has caused a global COVID-19 (coronavirus disease 2019) pandemic …
Revealing the inhibition mechanism of RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 by remdesivir and nucleotide analogues: A molecular dynamics …
PD Wakchaure, S Ghosh… - The Journal of Physical …, 2020 - ACS Publications
Antiviral drug therapy against SARS-CoV-2 is not yet established and posing a serious
global health issue. Remdesivir is the first antiviral compound approved by the US FDA for …
global health issue. Remdesivir is the first antiviral compound approved by the US FDA for …
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory …
The efforts towards developing a potential drug against the current global pandemic, COVID-
19, have increased in the past few months. Drug development strategies to target the RNA …
19, have increased in the past few months. Drug development strategies to target the RNA …
Impact of remdesivir incorporation along the primer strand on SARS-CoV-2 RNA-Dependent RNA polymerase
S Naseem-Khan, MB Berger, EM Leddin… - Journal of chemical …, 2022 - ACS Publications
Remdesivir was the first antiviral drug that received emergency use authorization from the
United States Food and Drug Administration and is now formally approved to treat COVID …
United States Food and Drug Administration and is now formally approved to treat COVID …
Structural basis of the potential binding mechanism of remdesivir to SARS-CoV-2 RNA-dependent RNA polymerase
Starting from late 2019, the coronavirus disease 2019 (COVID-19) has emerged as a once-
in-a-century pandemic with deadly consequences, which urgently calls for new treatments …
in-a-century pandemic with deadly consequences, which urgently calls for new treatments …
Intermolecular interaction among Remdesivir, RNA and RNA-dependent RNA polymerase of SARS-CoV-2 analyzed by fragment molecular orbital calculation
COVID-19, a disease caused by a new strain of coronavirus (SARS-CoV-2) originating from
Wuhan, China, has now spread around the world, triggering a global pandemic, leaving the …
Wuhan, China, has now spread around the world, triggering a global pandemic, leaving the …
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