Analgesic and sedative drugs are mostly used in an “off label” fashion in children. The
pharmacokinetic-pharmacodymamic (PK/PD) approach is useful in order to determine the …

Abstract Background and Objectives Fentanyl is a synthetic opioid commonly used as an
anesthetic and also increasingly popular as a sedative agent in neonates. Initial dosage …

Pharmacokinetic pharmacodynamic modeling is an important tool which uses statistical
methodology to provide a better understanding of the relationship between concentration …

Introduction: Assessment of analgesic drugs includes comparative studies to other
analgesics and local anesthesia blockade, number needed to treat estimates and opioid …

Background Fentanyl is commonly administered for procedural pain management in preterm
infants, but target concentrations have not yet been defined. Methods To investigate …

Abstract Background and Objective Fentanyl is an opioid commonly used to prevent and
treat severe pain in neonates; however, its use is off label and mostly based on bodyweight …

Objective Adequate data on fentanyl pharmacokinetics in neonates are lacking. The study
was performed to compare serum concentrations and clinical outcome between continuous …

Introduction Fentanyl is a frequently used analgesic in the neonatal intensive care unit
(NICU). Its minimal effect on hemodynamic stability, and its apparent exemption from the …

Aim Fentanyl pharmacokinetics and pharmacodynamics are lacking in preterm infants. Our
aim was to study these and their relation with a new formulation of fentanyl 5 μg/mL for …

Aims: Fentanyl is a potent opioid analgesic used within the hospital setting for the
management of acute pain within children following surgical procedures. The dosing of …