Lipoprotein (a) as a potential causal genetic risk factor of cardiovascular disease: a rationale for increased efforts to understand its pathophysiology and develop …

S Tsimikas, JL Hall - Journal of the American College of Cardiology, 2012 - jacc.org
Recent published studies have provided increasing evidence that lipoprotein (a)[Lp (a)] may
be a potential causal, genetic, independent risk factor for cardiovascular disease (CVD). Lp …

Lipoprotein (a): a genetically determined, causal, and prevalent risk factor for atherosclerotic cardiovascular disease: a scientific statement from the American Heart …

G Reyes-Soffer, HN Ginsberg, L Berglund… - … , and vascular biology, 2022 - Am Heart Assoc
High levels of lipoprotein (a)[Lp (a)], an apoB100-containing lipoprotein, are an independent
and causal risk factor for atherosclerotic cardiovascular diseases through mechanisms …

Association of LPA variants with risk of coronary disease and the implications for lipoprotein (a)-lowering therapies: a Mendelian randomization analysis

S Burgess, BA Ference, JR Staley, DF Freitag… - JAMA …, 2018 - jamanetwork.com
Importance Human genetic studies have indicated that plasma lipoprotein (a)(Lp [a]) is
causally associated with the risk of coronary heart disease (CHD), but randomized trials of …

Lipoprotein (a): when to measure and how to treat?

D Rhainds, MR Brodeur, JC Tardif - Current Atherosclerosis Reports, 2021 - Springer
Abstract Purpose of Review The purpose of this article is to review current evidence for
lipoprotein (a)(Lp (a)) as a risk factor for multiple cardiovascular (CV) disease phenotypes …

Lipoprotein (a) and cardiovascular and valvular diseases: a genetic epidemiological perspective

BJ Arsenault, PR Kamstrup - Atherosclerosis, 2022 - Elsevier
Rates of atherosclerotic cardiovascular diseases (CVD) in the Western world have
spectacularly decreased over the past 50 years. However, a substantial proportion of high …

Lipoprotein (a): a genetic marker for cardiovascular disease and target for emerging therapies

A Cesaro, A Schiavo, E Moscarella… - Journal of …, 2021 - journals.lww.com
Abstract Lipoprotein (a)[Lp (a)] is an established cardiovascular risk factor, and growing
evidence indicates its causal association with atherosclerotic disease because of the …

Lipoprotein (a) is markedly more atherogenic than LDL: an apolipoprotein B-based genetic analysis

E Björnson, M Adiels, MR Taskinen, S Burgess… - Journal of the American …, 2024 - jacc.org
Abstract Background Lipoprotein (a)(Lp (a)) is recognized as a causal factor for coronary
heart disease (CHD) but its atherogenicity relative to that of low-density lipoprotein (LDL) on …

A Common LPA Null Allele Associates With Lower Lipoprotein(a) Levels and Coronary Artery Disease Risk

T Kyriakou, U Seedorf, A Goel… - … , and vascular biology, 2014 - Am Heart Assoc
Objective—Increased levels of lipoprotein (a) are a highly heritable risk factor for coronary
artery disease (CAD). The genetic determinants of lipoprotein (a) levels are mainly because …

The renaissance of lipoprotein (a): brave new world for preventive cardiology?

KL Ellis, MB Boffa, A Sahebkar, ML Koschinsky… - Progress in Lipid …, 2017 - Elsevier
Abstract Lipoprotein (a)[Lp (a)] is a highly heritable cardiovascular risk factor. Although
discovered more than 50 years ago, Lp (a) has recently re-emerged as a major focus in the …

Lipoprotein (a) the insurgent: a new insight into the structure, function, metabolism, pathogenicity, and medications affecting lipoprotein (a) molecule

MM Jawi, J Frohlich, SY Chan - Journal of lipids, 2020 - Wiley Online Library
Lipoprotein (a)[Lp (a)], aka “Lp little a”, was discovered in the 1960s in the lab of the
Norwegian physician Kåre Berg. Since then, we have greatly improved our knowledge of …