Current therapies for lowering lipoprotein (a)

JC van Capelleveen, FM van der Valk… - Journal of lipid …, 2016 - ASBMB
Lipoprotein (a)[Lp (a)] is a human plasma lipoprotein with unique structural and functional
characteristics. Lp (a) is an assembly of two components: a central core with apoB and an …

Lipoprotein (a), platelet function and cardiovascular disease

HS Bhatia, RC Becker, G Leibundgut, M Patel… - Nature Reviews …, 2024 - nature.com
Abstract Lipoprotein (a)(Lp (a)) is associated with atherothrombosis through several
mechanisms, including putative antifibrinolytic properties. However, genetic association …

Lipoprotein (a) metabolism: potential sites for therapeutic targets

J Hoover-Plow, M Huang - Metabolism, 2013 - Elsevier
Lipoprotein (a)[Lp (a)] resembles low-density lipoprotein (LDL), with an LDL lipid core and
apolipoprotein B (apoB), but contains a unique apolipoprotein, apo (a). Elevated Lp (a) is an …

Elevated lipoprotein (a): background, current insights and future potential therapies

A Handhle, A Viljoen, AS Wierzbicki - Vascular Health and Risk …, 2021 - Taylor & Francis
Lipoprotein (a) forms a subfraction of the lipid profile and is characterized by the addition of
apolipprotein (a)(apo (a)) to apoB100 derived particles. Its levels are mostly genetically …

Diet and drug therapy for lipoprotein (a)

L Berglund - Current Opinion in Lipidology, 1995 - journals.lww.com
Lipoprotein (a) has been implicated with an increased risk of atherosclerosis and
cardiovascular disease. Recently, considerable progress has been made toward …

Lipoprotein (a): a historical appraisal

KM Kostner, GM Kostner - Journal of Lipid Research, 2017 - ASBMB
Initially, lipoprotein (a)[Lp (a)] was believed to be a genetic variant of lipoprotein (Lp)-B.
Because its lipid moiety is almost identical to LDL, Lp (a) has been deliberately considered …

When should we measure lipoprotein (a)?

KM Kostner, W März, GM Kostner - European heart journal, 2013 - academic.oup.com
Recently published epidemiological and genetic studies strongly suggest a causal
relationship of elevated concentrations of lipoprotein (a)[Lp (a)] with cardiovascular disease …

Oxidized phospholipids as a unifying theory for lipoprotein (a) and cardiovascular disease

MB Boffa, ML Koschinsky - Nature Reviews Cardiology, 2019 - nature.com
Epidemiological and clinical studies over the past decade have firmly established that
elevated plasma concentrations of lipoprotein (a)(Lp (a)) are an important, independent and …

Lipoprotein (a): novel target and emergence of novel therapies to lower cardiovascular disease risk

S Tsimikas - Current Opinion in Endocrinology, Diabetes and …, 2016 - journals.lww.com
Lipoprotein(a): novel target and emergence of novel therapie... : Current Opinion in
Endocrinology, Diabetes and Obesity Lipoprotein(a): novel target and emergence of novel …

Familial hypercholesterolemia and elevated lipoprotein (a): double heritable risk and new therapeutic opportunities

A Vuorio, GF Watts, WJ Schneider… - Journal of internal …, 2020 - Wiley Online Library
There is compelling evidence that the elevated plasma lipoprotein (a)[Lp (a)] levels increase
the risk of atherosclerotic cardiovascular disease (ASCVD) in the general population. Like …