N itric oxide (NO) is a recently appreciated regulator molecule for leukocytes, endothelial
cells of blood vessels, and neurons in the brain and peripheral nervous system. NO is …

Various cell types, including endothelial cells, can synthesize nitric oxide (NO). Three
different isoforms of NO synthase have been characterized, purified and cloned. Isozyme I is …

The formation of nitric oxide (NO) from the amino acid L-arginine is now recognized as a
ubiquitous pathway involved in a number of physiological functions. The generation of NO …

NO was first appreciated in mammalian physiology as a mediator of macrophage actions
(Nathan and Hibbs, 1991). Macrophages produce nitrates that derive from NO, whose …

Four recent discoveries have greatly increased interest in nitric oxide.(1) It has been shown
that the presence of NO is involved in several important biological events including vascular …

Endothelium-derived relaxing factor (EDRF) is a labile humoral agent released by vascular
endothelium that mediates the relaxation induced by some vasodilators, including …

The recent discovery of nitric oxide ('NO)'as a mammalian metabolic intermediate has
exploded into a swiftly developing area of research. The intense interest and rapid progress …

Nitric oxide (NO) is synthesized by at least three distinct isoforms of NO synthase (NOS).
Their substrate and cofactor requirements are very similar. All three isoforms have some …

Nitric oxide first captured the interest of biologists when this inorganic molecule was found to
activate cytosolic guanylate cyclase and stimulate cyclic guanosine monophosphate (GMP) …

Nitric oxide (NO) is a gaseous lipophilic free radical cellular messenger generated by three
distinct isoforms of nitric oxide synthases (NOS), neuronal (nNOS), inducible (iNOS) and …