The intrathecal synthesis of IgM in patients presenting with acute monosymptomatic
syndromes may be relevant in predicting eventual progression to multiple sclerosis but has …

Background: The intrathecal production of immunoglobulin (Ig) is a major biological feature
of multiple sclerosis (MS), and immunopathological studies have suggested a primary role of …

We reviewed the records of 391 patients who had presented with a Clinically Isolated
Syndrome and selected 205 who had performed a baseline spinal tap and MRI scan. We …

Intrathecal IgM synthesis (ITMS) predicts a worse evolution in the first stages of multiple
sclerosis (MS). The aim of this study was the follow‐up of a group of relapsing‐remitting MS …

The objective of this study was to investigate, whether the presence of oligoclonal
immunoglobulin M bands (IgM‐OCB) in cerebrospinal fluid (CSF) from patients with a …

A prospective study in patients with a clinical acute isolated brainstem or spinal cord
disorder was undertaken. The aim was to evaluate the predictive value of IgG intrathecal …

A combined clinical and magnetic resonance imaging follow‐up study was undertaken to
determine the risk of early progression to multiple sclerosis in patients who present with …

Background Most patients with multiple sclerosis initially present with a clinically isolated
syndrome. Despite the fact that clinically definite multiple sclerosis will develop in up to 80 …

Background: Previous studies have demonstrated that intrathecal synthesis of IgM is
observed in multiple sclerosis (MS) and correlates with a worse disease course. These …

Objectives To evaluate intrathecal immunoglobulin M (IgM) production, as compared to
previously established risk factors, as risk factor for conversion from clinically isolated …