The pathogenesis of neuropathic pain and its chronicization process are still not fully
elucidated. For this reason, therapies currently ongoing in the clinic are aimed to treat mostly …

Gamma-aminobutyric acid (GABA) is the main inhibitory/hyperpolarizing neurotransmitter in
the CNS, although it exerts important action also in the PNS. Glial Schwann cells (SC) …

GABA is a major inhibitory neurotransmitter in the mammalian central nervous system
(CNS). Inhibitory GABAA channel circuits in the dorsal spinal cord are the gatekeepers of the …

Background: Chronic pain is treated most commonly with opioid analgesics, anti-
inflammatory steroids and nonsteroidal anti-inflammatory drugs. Method: However, these …

Pain sensations experienced in the body, as well as in the orofacial region, convey to the
central nervous system (CNS) by peripheral sensory neurons such as the dorsal root …

Abstract Gamma-aminobutyric acid (GABA), a non-protein-producing amino acid
synthesized from the excitatory amino acid glutamate via the enzyme glutamic acid …

Chronic pain is an incapacitating condition that affects a large population worldwide. Until
now, there is no drug treatment to relieve it. The impairment of GABAergic inhibition …

Neuropathic pain is a type of chronic pain generated from an injury or disease of the
nervous system, producing a disabling condition in around 25 to 30% of the population …

A substantial fraction of the human population suffers from chronic pain states, which often
cannot be sufficiently treated with existing drugs. This calls for alternative targets and …

A substantial fraction of the human population suffers from chronic pain states, which often
cannot be sufficiently treated with existing drugs. This calls for alternative targets and …