[HTML][HTML] LncRNAs as chromatin regulators in cancer: from molecular function to clinical potential

R Begolli, N Sideris, A Giakountis - Cancers, 2019 - mdpi.com
During the last decade, high-throughput sequencing efforts in the fields of transcriptomics
and epigenomics have shed light on the noncoding part of the transcriptome and its …

Long non-coding RNAs and their implications in cancer epigenetics

FC Beckedorff, MS Amaral… - Bioscience …, 2013 - portlandpress.com
LncRNAs (long non-coding RNAs) have emerged as key molecular players in the regulation
of gene expression in different biological processes. Their involvement in epigenetic …

regulation of the cancer epigenome by long non-coding RNAs

ME Forrest, AM Khalil - Cancer Letters, 2017 - Elsevier
Long non-coding RNAs have emerged as highly versatile players in the regulation of gene
expression in development and human disease, particularly cancer. Hundreds of lncRNAs …

Alteration of epigenetic regulation by long noncoding RNAs in cancer

M Morlando, A Fatica - International journal of molecular sciences, 2018 - mdpi.com
Long noncoding RNAs (lncRNAs) are important regulators of the epigenetic status of the
human genome. Besides their participation to normal physiology, lncRNA expression and …

LncRNA: a link between RNA and cancer

G Yang, X Lu, L Yuan - Biochimica et Biophysica Acta (BBA)-Gene …, 2014 - Elsevier
Unraveling the gene expression networks governing cancer initiation and development is
essential while remains largely uncompleted. With the innovations in RNA-seq technologies …

LncRNAs in cancer: regulatory and therapeutic implications

A Nandwani, S Rathore, M Datta - Cancer letters, 2021 - Elsevier
Long noncoding RNAs (lncRNAs) comprise a class of RNAs that do not code for proteins but
are critical in regulating diverse cellular processes and maintaining cell function. In doing so …

Long noncoding RNAs: at the intersection of cancer and chromatin biology

AM Schmitt, HY Chang - Cold Spring …, 2017 - perspectivesinmedicine.cshlp.org
Although only 2% of the genome encodes protein, RNA is transcribed from the majority of
the genetic sequence, suggesting a massive degree of cellular functionality is programmed …

Perspectives of long non-coding RNAs in cancer diagnostics

EM Reis, S Verjovski-Almeida - Frontiers in genetics, 2012 - frontiersin.org
Long non-coding RNAs (lncRNAs) transcribed from intergenic and intronic regions of the
human genome constitute a broad class of cellular transcripts that are under intensive …

The talented LncRNAs: meshing into transcriptional regulatory networks in cancer

D Segal, J Dostie - Cancers, 2023 - mdpi.com
Simple Summary Long non-coding RNAs (lncRNAs) are a large class of RNA molecules
known to regulate the expression of genes. Although expressed in a highly tissue-specific …

LncRNAs in cancer: from garbage to junk

M Aprile, V Katopodi, E Leucci, V Costa - Cancers, 2020 - mdpi.com
Simple Summary Long non-coding RNAs (lncRNAs) are generally defined as transcripts
longer than 200 nucleotides and not coding for proteins. This review provides an overview of …