Objective—Macrophage (Mφ) migration rests on the adhesion/detachment between Mφ
surface components and extracellular matrixes, and the contribution of numerous …

Objective—Plasminogen activator inhibitor-1 (PAI-1), a serine protease inhibitor that
promotes and inhibits cell migration, plays a complex and important role in adverse vascular …

While inflammation is often associated with increased Plasminogen Activator Inhibitor-1 (PAI-
1), the functional consequences of PAI-1 in inflammation have yet to be fully determined …

Introduction: We determined the role of smooth muscle cell (SMC)-derived plasminogen
activator inhibitor-1 (PAI-1) in the flow-induced SMC migratory response. Materials and …

A new model for the actions of plasminogen activator inhibitors (PAIs) on cell migration may
resolve the conflicting research data on these proteins in metastasis and angiogenesis …

Introduction: Plasminogen activator inhibitor-1 (PAI-1) is critical in thrombus formation and
inflammation. Although these are essential pathological features of cardiovascular diseases …

Efficient migration of macrophages to sites of inflammation requires cell surface–bound
plasmin (ogen). Here, we investigated the mechanisms underlying the deficits of plasmin …

Inflammation plays a critical role in the development of cardiovascular diseases. Infiltration
of leukocytes to sites of injury requires their exit from the blood and migration across …

Migration of activated macrophages is essential for resolution of acute inflammation and the
initiation of adaptive immunity. Here, we show that efficient macrophage migration in …

Plasminogen activator inhibitor 1 (PAI-1) is the primary physiological inhibitor of
plasminogen activation in vivo, and thus it is one of the main regulators of the fibrinolytic …