[HTML][HTML] Endothelial nitric oxide synthase: a potential therapeutic target for cerebrovascular diseases

J Zhu, W Song, L Li, X Fan - Molecular brain, 2016 - Springer
Endothelial nitric oxide (NO) is a significant signaling molecule that regulates cerebral blood
flow (CBF), playing a pivotal role in the prevention and treatment of cerebrovascular …

Role of endothelial nitric oxide in cerebrovascular regulation

DN Atochin, PL Huang - Current pharmaceutical …, 2011 - ingentaconnect.com
Endothelial nitric oxide (NO) plays important roles in the vascular system. Animal models
that show vascular dysfunction demonstrate the protective role of endothelial NO dependent …

Targeting eNOS for stroke protection

M Endres, U Laufs, JK Liao, MA Moskowitz - Trends in neurosciences, 2004 - cell.com
Nitric oxide (NO) generated by endothelial NO synthase (eNOS) plays a crucial role in
vascular function and homeostasis. NO possesses vasodilatory, anti-inflammatory …

Nitric oxide and cerebrovascular regulation

SN Tabatabaei, H Girouard - Vitamins & hormones, 2014 - Elsevier
The cerebrovascular regulation involves highly complex mechanisms to assure that the
brain is perfused at all times. These mechanisms depend on all components of the …

Current therapeutic strategies to mitigate the eNOS dysfunction in ischaemic stroke

K Srivastava, PMW Bath, U Bayraktutan - Cellular and molecular …, 2012 - Springer
Impairment of endothelial nitric oxide synthase (eNOS) activity is implicated in the
pathogenesis of endothelial dysfunction in many diseases including ischaemic stroke. The …

Up-regulation of endothelial nitric oxide activity as a central strategy for prevention of ischemic stroke–just say NO to stroke!

MF McCarty - Medical hypotheses, 2000 - Elsevier
Nitric oxide (NO) produced by the endothelium of cerebral arterioles is an important
mediator of endothelium-dependent vasodilation (EDV), and also helps to prevent …

Protecting the brain with eNOS: run for your life

FM Faraci - Circulation research, 2006 - Am Heart Assoc
Nitric oxide (NO) plays a major role in both vascular and neural biology in health and
disease. This concept is exemplified when one examines the role of NO in the brain and the …

Neurovascular protective function of endothelial nitric oxide–recent advances–

ZS Katusic, SA Austin - Circulation Journal, 2016 - jstage.jst.go.jp
In the central nervous system endothelial nitric oxide (NO) is an essential molecule
responsible for the preservation of the functional integrity of the neurovascular unit. NO …

Endothelial nitric oxide synthase protects neurons against ischemic injury through regulation of brain‐derived neurotrophic factor expression

ST Li, J Pan, XM Hua, H Liu, S Shen… - CNS neuroscience & …, 2014 - Wiley Online Library
Aims Several lines of evidence demonstrated that endothelial nitric oxide synthase (eNOS)
confers protective effects during cerebral ischemia. In this study, we explored the underlying …

Endothelial nitric oxide: protector of a healthy mind

ZS Katusic, SA Austin - European heart journal, 2014 - academic.oup.com
Endothelial nitric oxide (NO) is generated by constitutively active endothelial nitric oxide
synthase (eNOS), an essential enzyme responsible for cardiovascular homeostasis …