Role of ADAMTS-5 in aortic dilatation and extracellular matrix remodeling
M Fava, J Barallobre-Barreiro, U Mayr… - … , and vascular biology, 2018 - Am Heart Assoc
Objective—Thoracic aortic aneurysm (TAA), a degenerative disease of the aortic wall, is
accompanied by changes in the structure and composition of the aortic ECM (extracellular …
accompanied by changes in the structure and composition of the aortic ECM (extracellular …
Critical role of ADAMTS-4 in the development of sporadic aortic aneurysm and dissection in mice
Sporadic aortic aneurysm and dissections (AADs) are common vascular diseases that carry
a high mortality rate. ADAMTS-4 (a disintegrin-like and metalloproteinase with …
a high mortality rate. ADAMTS-4 (a disintegrin-like and metalloproteinase with …
ADAMTS-1 in abdominal aortic aneurysm
E Vorkapic, M Folkesson, K Magnell, M Bohlooly-Y… - PLoS …, 2017 - journals.plos.org
Introduction Extracellular matrix degradation is a hallmark of abdominal aortic aneurysm
(AAA). Among proteases that are capable of degrading extracellular matrix are a disintegrin …
(AAA). Among proteases that are capable of degrading extracellular matrix are a disintegrin …
Role of ADAMTS-1 in atherosclerosis: remodeling of carotid artery, immunohistochemistry, and proteolysis of versican
AC Jönsson-Rylander, T Nilsson… - … , and vascular biology, 2005 - Am Heart Assoc
Objective—We investigated the potential role of ADAMTS-1 (a disintegrin and
metalloprotease with thrombospondin motif type I) in atherogenesis. Methods and Results …
metalloprotease with thrombospondin motif type I) in atherogenesis. Methods and Results …
ADAMTS proteins and vascular remodeling in aortic aneurysms
Extracellular matrix (ECM) in the vascular wall is a highly dynamic structure composed of a
set of different molecules such as elastins, collagens, fibronectin (Fn), laminins …
set of different molecules such as elastins, collagens, fibronectin (Fn), laminins …
Novel role of ADAMTS-5 protein in proteoglycan turnover and lipoprotein retention in atherosclerosis
Atherosclerosis is initiated by the retention of lipoproteins on proteoglycans in the arterial
intima. However, the mechanisms leading to proteoglycan accumulation and lipoprotein …
intima. However, the mechanisms leading to proteoglycan accumulation and lipoprotein …
Postnatal deficiency of ADAMTS1 ameliorates thoracic aortic aneurysm and dissection in mice
S Wang, Y Liu, G Zhao, L He, Y Fu, C Yu… - Experimental …, 2018 - Wiley Online Library
New Findings What is the central question of this study? Thoracic aortic aneurysm and
dissection (TAAD) is characterized by extracellular matrix remodelling and an inflammatory …
dissection (TAAD) is characterized by extracellular matrix remodelling and an inflammatory …
Loss of ADAMTS4 reduces high fat diet-induced atherosclerosis and enhances plaque stability in ApoE−/− mice
Atherosclerosis is a chronic inflammatory disease characterized by formation of lipid-rich
plaques on the inner walls of arteries. ADAMTS4 (a disintegrin-like and metalloproteinase …
plaques on the inner walls of arteries. ADAMTS4 (a disintegrin-like and metalloproteinase …
Cell-specific functions of ADAM17 regulate the progression of thoracic aortic aneurysm
Rationale: ADAM17 (a disintegrin and metalloproteinase-17) is a membrane-bound enzyme
that regulates bioavailability of multiple transmembrane proteins by proteolytic processing …
that regulates bioavailability of multiple transmembrane proteins by proteolytic processing …
Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4
JD Sandy, J Westling, RD Kenagy… - Journal of Biological …, 2001 - ASBMB
Mature human aorta contains a 70-kDa versican fragment, which reacts with a neoepitope
antiserum to the C-terminal peptide sequence DPEAAE. This protein therefore appears to …
antiserum to the C-terminal peptide sequence DPEAAE. This protein therefore appears to …