Hippocampal somatostatin interneurons, long-term synaptic plasticity and memory

E Honoré, A Khlaifia, A Bosson… - Frontiers in neural circuits, 2021 - frontiersin.org
A distinctive feature of the hippocampal structure is the diversity of inhibitory interneurons.
These complex inhibitory interconnections largely contribute to the tight modulation of …

Disinhibition in learning and memory circuits: New vistas for somatostatin interneurons and long-term synaptic plasticity

J Artinian, JC Lacaille - Brain research bulletin, 2018 - Elsevier
Neural circuit functions involve finely controlled excitation/inhibition interactions that allow
complex neuronal computations and support high order brain functions such as learning …

Presynaptic GABAB receptors functionally uncouple somatostatin interneurons from the active hippocampal network

SA Booker, H Harada, C Elgueta, J Bank, M Bartos… - Elife, 2020 - elifesciences.org
Information processing in cortical neuronal networks relies on properly balanced excitatory
and inhibitory neurotransmission. A ubiquitous motif for maintaining this balance is the …

Astrocytes detect and upregulate transmission at inhibitory synapses of somatostatin interneurons onto pyramidal cells

M Matos, A Bosson, I Riebe, C Reynell, J Vallée… - Nature …, 2018 - nature.com
Astrocytes are important regulators of excitatory synaptic networks. However, astrocytes
regulation of inhibitory synaptic systems remains ill defined. This is particularly relevant …

Interneuron-specific signaling evokes distinctive somatostatin-mediated responses in adult cortical astrocytes

L Mariotti, G Losi, A Lia, M Melone… - Nature …, 2018 - nature.com
The signaling diversity of GABAergic interneurons to post-synaptic neurons is crucial to
generate the functional heterogeneity that characterizes brain circuits. Whether this diversity …

Somatostatin-expressing inhibitory interneurons in cortical circuits

I Yavorska, M Wehr - Frontiers in neural circuits, 2016 - frontiersin.org
Cortical inhibitory neurons exhibit remarkable diversity in their morphology, connectivity, and
synaptic properties. Here, we review the function of somatostatin-expressing (SOM) …

Somatostatin-positive interneurons in the dentate gyrus of mice provide local-and long-range septal synaptic inhibition

M Yuan, T Meyer, C Benkowitz, S Savanthrapadian… - Elife, 2017 - elifesciences.org
Somatostatin-expressing-interneurons (SOMIs) in the dentate gyrus (DG) control formation
of granule cell (GC) assemblies during memory acquisition. Hilar-perforant-path-associated …

Somatostatin-expressing interneurons form axonal projections to the contralateral hippocampus

MD Eyre, M Bartos - Frontiers in Neural Circuits, 2019 - frontiersin.org
Conscious memories are critically dependent upon bilateral hippocampal formation, and
interhemispheric commissural projections made by mossy cells and CA3 pyramidal cells …

Somatostatin interneurons inhibit excitatory transmission mediated by astrocytic GABAB and presynaptic GABAB and adenosine A1 receptors in the hippocampus

W Shen, Z Li, Y Tang, P Han, F Zhu… - Journal of …, 2022 - Wiley Online Library
GABAergic network activity has been established to be involved in numerous physiological
processes and pathological conditions. Extensive studies have corroborated that GABAergic …

Somatostatin and parvalbumin inhibitory synapses onto hippocampal pyramidal neurons are regulated by distinct mechanisms

ME Horn, RA Nicoll - … of the National Academy of Sciences, 2018 - National Acad Sciences
Excitation–inhibition balance is critical for optimal brain function, yet the mechanisms
underlying the tuning of inhibition from different populations of inhibitory neurons are …