VAR2CSA Domains Expressed in Escherichia coli Induce Cross-Reactive Antibodies to Native Protein
AV Oleinikov, SE Francis, JR Dorfman… - The Journal of …, 2008 - academic.oup.com
The variant surface antigen VAR2CSA is a pregnancy malaria vaccine candidate, but its size
and polymorphism are obstacles to development. We expressed 3D7-type VAR2CSA …
and polymorphism are obstacles to development. We expressed 3D7-type VAR2CSA …
Optimizing expression of the pregnancy malaria vaccine candidate, VAR2CSA in Pichia pastoris
M Avril, MJ Hathaway, MM Cartwright, SO Gose… - Malaria Journal, 2009 - Springer
Background VAR2CSA is the main candidate for a vaccine against pregnancy-associated
malaria, but vaccine development is complicated by the large size and complex disulfide …
malaria, but vaccine development is complicated by the large size and complex disulfide …
Induction of strain-transcendent antibodies to placental-type isolates with VAR2CSA DBL3 or DBL5 recombinant proteins
Background Pregnancy associated malaria is a severe clinical syndrome associated with
sequestration of Plasmodium falciparum-infected erythrocytes in the placenta. Placental …
sequestration of Plasmodium falciparum-infected erythrocytes in the placenta. Placental …
Effects of sex, parity, and sequence variation on seroreactivity to candidate pregnancy malaria vaccine antigens
AV Oleinikov, E Rossnagle, S Francis… - The Journal of …, 2007 - academic.oup.com
Background. Plasmodium falciparum-infected erythrocytes adhere to chondroitin sulfate A
(CSA) to sequester in the human placenta, and pregnancy malaria (PM) is associated with …
(CSA) to sequester in the human placenta, and pregnancy malaria (PM) is associated with …
Evidence for globally shared, cross-reacting polymorphic epitopes in the pregnancy-associated malaria vaccine candidate VAR2CSA
M Avril, BR Kulasekara, SO Gose, C Rowe… - Infection and …, 2008 - Am Soc Microbiol
Pregnancy-associated malaria (PAM) is characterized by the placental sequestration of
Plasmodium falciparum-infected erythrocytes (IEs) with the ability to bind to chondroitin …
Plasmodium falciparum-infected erythrocytes (IEs) with the ability to bind to chondroitin …
Antibodies to a full-length VAR2CSA immunogen are broadly strain-transcendent but do not cross-inhibit different placental-type parasite isolates
M Avril, MJ Hathaway, A Srivastava, S Dechavanne… - PloS one, 2011 - journals.plos.org
The high molecular weight, multidomain VAR2CSA protein mediating adhesion of
Plasmodium falciparum-infected erythrocytes in the placenta is the leading candidate for a …
Plasmodium falciparum-infected erythrocytes in the placenta is the leading candidate for a …
Baculovirus-Expressed Constructs Induce Immunoglobulin G That Recognizes VAR2CSA on Plasmodium falciparum- Infected Erythrocytes
We raised specific antisera against recombinant VAR2CSA domains produced in
Escherichia coli and in insect cells. All were reactive in enzyme-linked immunosorbent …
Escherichia coli and in insect cells. All were reactive in enzyme-linked immunosorbent …
Antibodies to Escherichia coli-expressed C-terminal domains of Plasmodium falciparum variant surface antigen 2-chondroitin sulfate A (VAR2CSA) inhibit binding of …
T Saveria, AV Oleinikov, K Wiliamson… - Infection and …, 2013 - Am Soc Microbiol
Placental malaria (PM) is characterized by infected erythrocytes (IEs) that selectively bind to
chondroitin sulfate A (CSA) and sequester in placental tissue. Variant surface antigen 2-CSA …
chondroitin sulfate A (CSA) and sequester in placental tissue. Variant surface antigen 2-CSA …
Parity-dependent recognition of DBL1X-3X suggests an important role of the VAR2CSA high-affinity CSA-binding region in the development of the humoral response …
S Dechavanne, A Srivastava, S Gangnard… - Infection and …, 2015 - Am Soc Microbiol
Plasmodium falciparum multidomain protein VAR2CSA stands today as the leading vaccine
candidate against pregnancy-associated malaria (PAM). Most of the studies aiming to …
candidate against pregnancy-associated malaria (PAM). Most of the studies aiming to …
Structure of the DBL3X-DBL4ε region of the VAR2CSA placental malaria vaccine candidate: insight into DBL domain interactions
S Gangnard, A Lewit-Bentley, S Dechavanne… - Scientific reports, 2015 - nature.com
The human malaria parasite, Plasmodium falciparum, is able to evade spleen-mediated
clearing from blood stream by sequestering in peripheral organs. This is due to the adhesive …
clearing from blood stream by sequestering in peripheral organs. This is due to the adhesive …