Osteosarcoma or chondrosarcoma developed as a second malignant neoplasm (SMN) in 40
of 188 individuals with SMN whose first neoplasm occurred in childhood. A genetic …

A search of the records of 10 pediatric oncology centers revealed 102 children with more
than one malignant neoplasm. In this group of 102 patients, all pediatric cancers were seen …

This study explores the relationship between histologic variants of bone sarcomas and
previous therapy in patients in whom an unrelated malignant neoplasm had been …

Familial cancer is manifested by the early development of histologically different
malignancies in multiple members of a family at different anatomical sites. Two or more …

One hundred fifty-nine 3-year survivors of childhood soft tissue sarcoma and their relatives
were surveyed to determine the frequency of second malignant neoplasms (SMNs) in …

Studies to determine the etiology of osteosarcoma involve epidemiologic and environmental
factors and genetic impairments. Factors related to patient characteristics include age …

Currently, approximately 67% of children diagnosed with cancer can be expected to survive
more than 5 years. Among the most significant late effects of cancer therapy is the …

Three brothers had separate childhood cancers—osteogenic sarcoma, acute lymphoblastic
leukemia, and bilateral malignant neurilemoma. Comprehensive family history showed a …

Background. Childhood soft tissue sarcomas are known to occur in a number of genetic
syndromes. This study assesses the proportion of soft tissue sarcoma diagnosed in …

Nine patients who had an osteosarcoma that had developed as a second malignant
neoplasm in a previously irradiated site were managed at a major center for the treatment of …