The mechanism of the recently described N→ C direction peptide synthesis through silver‐
promoted coupling of N‐protected amino acids with thioacetylated amino esters was …

The Ag (I)-promoted coupling of amino acids and peptides with amino ester thioamides
generates peptide imides without epimerisation. The peptide imides undergo regioselective …

Here we solve a long-standing challenge of the site-selective modification of secondary
amides and present a simple two-step, metal-free approach to selectively modify a particular …

The development of methods for amide bond formation without recourse to typical
condensation reagents has become an emerging research area and has been actively …

In the present paper, systematic studies revealed that Cu (I) salts in general and Cu (II) salts
under certain circumstances promote effective reaction between peptide thiol esters and the …

A copper (II)/HOBt-catalyzed procedure for the synthesis of dipeptides and “general” amides
has been developed using microwave irradiation to considerably hasten the reaction. As an …

A new bio-inspired approach is reported for amide and peptide synthesis using α-amino
esters that possess a potential activating group (PAG) at the ester residue. To activate the …

Rapid and efficient preparation of peptide thioacids from 2-cyanoethyl peptide thioesters has
been accomplished. S-2-Cyanoethyl peptide thioesters were obtained cleanly without the …

Amino acids and peptides with bulky side chains are of significant importance in organic
synthesis and modern medicinal chemistry. The efficient synthesis of these molecules with …

Coupling reagents based on onium (aminium/uronium) salts based on HOBt and HOAt are
more frequently used in solid-phase peptide synthesis than the classical carbodiimide …