A major challenge in developing stroke therapeutics that augment adaptive pathways to
stress has been to identify targets that can activate compensatory programs without inducing …

Ischemic stroke is a major cause of death worldwide, and current therapeutic options are
very limited. Preconditioning with an ischemic or hypoxic insult is beneficial in experimental …

Every year stroke claims more than 6 million lives worldwide. The majority of them are
ischemic stroke. Small molecule-based therapeutics for ischemic stroke has attracted a lot of …

Ischemic stroke results in disruption of the blood-brain barrier (BBB), edema formation and
neuronal cell loss. Some neuroprotective factors such as vascular endothelial growth factor …

Key points• Cerebral ischaemia results in the activation of multiple pathways that can
independently lead to neuronal death. Agents targeting a number of processes at one time …

Acute ischemic stroke (AIS) is the primary reason for sustained disability and the second
leading cause of death worldwide. Multiple complex mechanisms contribute to the …

Hypoxia inducible factor (HIF) is the master oxygen sensor within cells and is central to the
regulation of cell responses to varying oxygen levels. HIF activation during hypoxia ensures …

Background and Purpose—Numerous factors involved in the adaptive response to hypoxia,
including erythropoietin and vascular endothelial growth factor are transcriptionally …

Oxidative stress contributes to tissue injury in conditions ranging from cardiovascular
disease to stroke, spinal cord injury, neurodegeneration, and perhaps even aging. Yet the …

Pathological oxygen deprivation inhibits prolyl hydroxylase (PHD) activity and stimulates a
protective cellular oxygen-sensing response in part through the stabilization and activation …