Background Role of multidrug resistance-1 (MDR-1) gene polymorphisms has not been
clarified in nephrotic syndrome (NS). Additionally, researchers studied several genetic …

Background. The putative genetic regulation of multidrug resistance gene-1 (MDR-1) gene
expression and P-glycoprotein function has not yet been clearly delineated in patients with …

Background: Oral steroid treatment is the first line of therapy for childhood nephrotic
syndrome (NS). However, resistance to this treatment has been observed in some patients …

Background: Studies have investigated rs1128503, rs1045642, and rs2032582 in multidrug
resistance protein 1 (MDR1) for association with susceptibility to idiopathic nephrotic …

The study was aimed at investigating the association between MDR-1 genetic
polymorphisms [C1236T, G2677T (A), C3435T] and parameters describing the clinical …

Aim: The purpose of the study was to investigate the distribution of insertion/deletion (I/D)
polymorphisms of the angiotensin-converting enzyme (ACE) gene and three exonic …

Polymorphic variants in several molecules involved in the glomerular function and drug
metabolism have been implicated in the pathophysiology of pediatric idiopathic nephrotic …

Background The role of the multidrug resistance-1 (MDR1 or ABCB1) gene polymorphisms
1236T> C, 2677T> G, and 3435T> C was studied in relation to susceptibility, demographics …

Oral steroid treatment is the first line of therapy for childhood nephrotic syndrome (NS).
Nonetheless, some patients are resistant to this treatment. Many efforts have been made to …

Aim: P‐glycoprotein is localized at the apical brush‐border membrane of the proximal renal
tubule and functions as extruding toxins and xenobiotics out of cells. The difference of P …