[HTML][HTML] Targeting the CD40-CD40L pathway in autoimmune diseases: Humoral immunity and beyond
JL Karnell, SA Rieder, R Ettinger, R Kolbeck - Advanced drug delivery …, 2019 - Elsevier
CD40 is a TNF receptor superfamily member expressed on both immune and non-immune
cells. Interactions between B cell-expressed CD40 and its binding partner, CD40L …
cells. Interactions between B cell-expressed CD40 and its binding partner, CD40L …
Therapeutic interventions targeting CD40L (CD154) and CD40: the opportunities and challenges
CL Law, IS Grewal - Therapeutic targets of the TNF superfamily, 2009 - Springer
CD40 was originally identified as a receptor on B-cells that delivers contact-dependent T
helper signals to B-cells through interaction with CD40 ligand (CD40L, CD154). The pivotal …
helper signals to B-cells through interaction with CD40 ligand (CD40L, CD154). The pivotal …
CD40 and its crucial role as a member of the TNFR family
LA Vogel, RJ Noelle - Seminars in immunology, 1998 - Elsevier
The cell surface molecule CD40 is a member of the tumor necrosis factor receptor (TNFR)
family and plays a pivotal role in the immune system due in part to its wide tissue …
family and plays a pivotal role in the immune system due in part to its wide tissue …
Molecular mechanism and function of CD40/CD40L engagement in the immune system
R Elgueta, MJ Benson, VC De Vries… - Immunological …, 2009 - Wiley Online Library
During the generation of a successful adaptive immune response, multiple molecular
signals are required. A primary signal is the binding of cognate antigen to an antigen …
signals are required. A primary signal is the binding of cognate antigen to an antigen …
The role of CD40 in peripheral T cell tolerance and immunity
L Diehl, AT Den Boer, EIH Van der Voort… - Journal of molecular …, 2000 - Springer
Abstract CD40 and CD40 ligand (CD40L) have been implicated as important molecules for
the transformation of nonactivated antigen-presenting cells (APC) into cells that are potent …
the transformation of nonactivated antigen-presenting cells (APC) into cells that are potent …
CD40 and autoimmunity: the dark side of a great activator
AL Peters, LL Stunz, GA Bishop - Seminars in immunology, 2009 - Elsevier
CD40 is a tumor necrosis factor receptor superfamily member expressed by immune and
non-immune cells. CD40: CD154 interactions mediate T-dependent B cell responses and …
non-immune cells. CD40: CD154 interactions mediate T-dependent B cell responses and …
Mechanistic basis of co-stimulatory CD40-CD40L ligation mediated regulation of immune responses in cancer and autoimmune disorders
Generation of an accurate humoral and a cell mediated adaptive immune responsesare
dictated by binding of an antigen to a T-and a B-cell receptor, respectively (first signal) …
dictated by binding of an antigen to a T-and a B-cell receptor, respectively (first signal) …
Functions of CD40 on B cells, dendritic cells and other cells
C van Kooten, J Banchereau - Current opinion in immunology, 1997 - Elsevier
CD40 is a cell surface receptor that belongs to the tumor necrosis factor receptor family. It
was first identified and functionally characterized on B lymphocytes; however, in recent …
was first identified and functionally characterized on B lymphocytes; however, in recent …
CD40‐CD40 ligand
C van Kooten, J Banchereau - Journal of leukocyte biology, 2000 - Wiley Online Library
CD40 is a cell surface receptor that belongs to the tumor necrosis factor‐R (TNF‐R) family,
and that was first identified and functionally characterized on B lymphocytes. Its critical role …
and that was first identified and functionally characterized on B lymphocytes. Its critical role …
The Cd40 ligand: The center of the immune universe?
IS Grewal, RA Flavell - Immunologic research, 1997 - Springer
For several years, the primary function of CD40 ligand (CD40L) has been believed to be in
regulation of contact-dependent, CD40-CD40L-mediated signals between B-and T-cells …
regulation of contact-dependent, CD40-CD40L-mediated signals between B-and T-cells …