The cell-surface molecule CD40, a member of the tumor necrosis factor receptor
superfamily, broadly regulates immune activation and mediates tumor apoptosis. CD40 is …

The CD40 receptor is expressed constitutively on B lymphocytes, for which it provides
important signals regulating clonal expansion, antibody production and isotype switching, as …

The first signal is antigen specific; it is delivered via the antigen-specific T-cell surface
receptor (TCR) when antigen is properly presented to the T cell in the context of major …

Initially, a role for the interaction between CD40, expressed on B cells, and gp39 (CD40L),
expressed on activated T cells, has been defined in humoral immunity. CD40-CD40L …

CD40 is expressed on a diverse array of cell types from the hematopoeitic and non-
hematopoeitic compartments. Within the hematopoeitic compartment, CD40 is found …

CD40, a transmembrane receptor of the tumor necrosis factor gene superfamily is expressed
on a variety of cells, such as monocytes, B‐cells, antigen presenting cells, endothelial …

ABSTRACT Cluster of differentiation 40 (CD40) is a member of the tumour necrosis factor
family and a new immune-modulating target in cancer treatment. B cells, myeloid cells and …

CD40 is a tumour necrosis factor receptor family member that is overexpressed in a broad
range of leukaemias, lymphomas and carcinomas, and could contribute to their …

Research in the past few years has documented significant advances in our understanding
of the CD40–CD40 ligand (CD154) system in diverse immune functions. This system …

Abstract The CD40: CD40 ligand (CD40L) interaction provides T lymphocyte‐mediated help
for B lymphocyte and monocyte function but has also been shown to serve as a co‐stimulus …