RAF‐targeted therapy for hepatocellular carcinoma in the regenerating liver
Background Post‐operative liver regeneration may contribute to tumor recurrence. There is
a theoretical need for an adjuvant therapy that can suppress tumor growth without adversely …
a theoretical need for an adjuvant therapy that can suppress tumor growth without adversely …
The effects of sorafenib on liver regeneration in a model of partial hepatectomy
PC Kurniali, K O'Gara, X Wang, LJ Wang… - journal of surgical …, 2012 - Elsevier
BACKGROUND: Sorafenib is currently approved for advanced hepatocellular carcinoma
(HCC) and is presently being studied as an adjuvant treatment for HCC following resection …
(HCC) and is presently being studied as an adjuvant treatment for HCC following resection …
[PDF][PDF] Effect of sorafenib on murine liver regeneration
C Hora, P Romanque, JFF Dufour - Hepatology, 2011 - Wiley Online Library
Hepatocellular carcinoma (HCC) is a common cause of cancer‐related death. Sorafenib
prolongs survival of patients with advanced disease and is approved for the systemic …
prolongs survival of patients with advanced disease and is approved for the systemic …
Sorafenib prolongs liver regeneration after hepatic resection in rats
A Mollbrink, M Augsten, R Hultcrantz… - journal of surgical …, 2013 - Elsevier
Background The multikinase inhibitor sorafenib inhibits angiogenesis and tumor cell
proliferation. Sorafenib targets signaling pathways involved in liver regeneration. Previous …
proliferation. Sorafenib targets signaling pathways involved in liver regeneration. Previous …
[HTML][HTML] The effect of sorafenib on liver regeneration and angiogenesis after partial hepatectomy in rats
K Kiroplastis, I Fouzas, E Katsiki, K Patsiaoura… - Hippokratia, 2015 - ncbi.nlm.nih.gov
Background Liver regeneration is vital for the survival of patients submitted to extensive liver
resection as a treatment of hepatocellular carcinoma (HCC). Sorafenib is a multikinase …
resection as a treatment of hepatocellular carcinoma (HCC). Sorafenib is a multikinase …
[PDF][PDF] Sorafenib suppresses postsurgical recurrence and metastasis of hepatocellular carcinoma in an orthotopic mouse model
Surgical resection is the first‐line treatment for hepatocellular carcinoma (HCC) patients with
well‐preserved liver function. Nevertheless, the rate of postoperative recurrence at 5 years is …
well‐preserved liver function. Nevertheless, the rate of postoperative recurrence at 5 years is …
The outcome of sorafenib therapy on unresectable hepatocellular carcinoma: experience of conversion and salvage hepatectomy
T Yoshimoto, S Imura, Y Morine, T Ikemoto… - Anticancer …, 2018 - ar.iiarjournals.org
Background/Aim: We report the outcomes of sorafenib therapy for advanced hepatocellular
carcinoma (HCC) in our Department. Patients and Methods: Thirty-eight patients with …
carcinoma (HCC) in our Department. Patients and Methods: Thirty-eight patients with …
[HTML][HTML] Extending survival with the use of targeted therapy in the treatment of hepatocellular carcinoma
RG Gish, RS Finn, JA Marrero - Gastroenterology & hepatology, 2013 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide, with an
increasing incidence projected through 2020. HCC is the third-leading cause of cancer …
increasing incidence projected through 2020. HCC is the third-leading cause of cancer …
An investigation of the effect of sorafenib on tumour growth and recurrence after liver cancer resection in nude mice independent of phosphorylated extracellular …
Z Wang, J Hu, SJ Qiu, XW Huang, Z Dai… - Expert opinion on …, 2011 - Taylor & Francis
Objective: The goal of this study is to investigate the effects of sorafenib on tumor growth,
recurrence and metastasis after curative resection of liver cancer. Research methods …
recurrence and metastasis after curative resection of liver cancer. Research methods …
[HTML][HTML] Hepatocellular carcinoma cases with high levels of c-Raf-1 expression may benefit from postoperative adjuvant sorafenib after hepatic resection even with …
J Lei, J Zhong, J Hao, Z Liu, P Zhang, L Wu, L Yan… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Results Most of the cases of HCC were caused by hepatitis B virus (HBV) infection (23
cases, 92%). Most of these tumors (21 cases, 84%) were stage III according to the TNM …
cases, 92%). Most of these tumors (21 cases, 84%) were stage III according to the TNM …