RAF‐targeted therapy for hepatocellular carcinoma in the regenerating liver

JH Shi, SZ Liu, L Wierød, H Scholz… - Journal of surgical …, 2013 - Wiley Online Library
Background Post‐operative liver regeneration may contribute to tumor recurrence. There is
a theoretical need for an adjuvant therapy that can suppress tumor growth without adversely …

The effects of sorafenib on liver regeneration in a model of partial hepatectomy

PC Kurniali, K O'Gara, X Wang, LJ Wang… - journal of surgical …, 2012 - Elsevier
BACKGROUND: Sorafenib is currently approved for advanced hepatocellular carcinoma
(HCC) and is presently being studied as an adjuvant treatment for HCC following resection …

[PDF][PDF] Effect of sorafenib on murine liver regeneration

C Hora, P Romanque, JFF Dufour - Hepatology, 2011 - Wiley Online Library
Hepatocellular carcinoma (HCC) is a common cause of cancer‐related death. Sorafenib
prolongs survival of patients with advanced disease and is approved for the systemic …

Sorafenib prolongs liver regeneration after hepatic resection in rats

A Mollbrink, M Augsten, R Hultcrantz… - journal of surgical …, 2013 - Elsevier
Background The multikinase inhibitor sorafenib inhibits angiogenesis and tumor cell
proliferation. Sorafenib targets signaling pathways involved in liver regeneration. Previous …

[HTML][HTML] The effect of sorafenib on liver regeneration and angiogenesis after partial hepatectomy in rats

K Kiroplastis, I Fouzas, E Katsiki, K Patsiaoura… - Hippokratia, 2015 - ncbi.nlm.nih.gov
Background Liver regeneration is vital for the survival of patients submitted to extensive liver
resection as a treatment of hepatocellular carcinoma (HCC). Sorafenib is a multikinase …

[PDF][PDF] Sorafenib suppresses postsurgical recurrence and metastasis of hepatocellular carcinoma in an orthotopic mouse model

YX Feng, T Wang, YZ Deng, P Yang, JJ Li… - …, 2011 - Wiley Online Library
Surgical resection is the first‐line treatment for hepatocellular carcinoma (HCC) patients with
well‐preserved liver function. Nevertheless, the rate of postoperative recurrence at 5 years is …

The outcome of sorafenib therapy on unresectable hepatocellular carcinoma: experience of conversion and salvage hepatectomy

T Yoshimoto, S Imura, Y Morine, T Ikemoto… - Anticancer …, 2018 - ar.iiarjournals.org
Background/Aim: We report the outcomes of sorafenib therapy for advanced hepatocellular
carcinoma (HCC) in our Department. Patients and Methods: Thirty-eight patients with …

[HTML][HTML] Extending survival with the use of targeted therapy in the treatment of hepatocellular carcinoma

RG Gish, RS Finn, JA Marrero - Gastroenterology & hepatology, 2013 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide, with an
increasing incidence projected through 2020. HCC is the third-leading cause of cancer …

An investigation of the effect of sorafenib on tumour growth and recurrence after liver cancer resection in nude mice independent of phosphorylated extracellular …

Z Wang, J Hu, SJ Qiu, XW Huang, Z Dai… - Expert opinion on …, 2011 - Taylor & Francis
Objective: The goal of this study is to investigate the effects of sorafenib on tumor growth,
recurrence and metastasis after curative resection of liver cancer. Research methods …

[HTML][HTML] Hepatocellular carcinoma cases with high levels of c-Raf-1 expression may benefit from postoperative adjuvant sorafenib after hepatic resection even with …

J Lei, J Zhong, J Hao, Z Liu, P Zhang, L Wu, L Yan… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Results Most of the cases of HCC were caused by hepatitis B virus (HBV) infection (23
cases, 92%). Most of these tumors (21 cases, 84%) were stage III according to the TNM …