Distinctive features of tumor-infiltrating γδ T lymphocytes in human colorectal cancer

S Meraviglia, E Lo Presti, M Tosolini… - …, 2017 - Taylor & Francis
ABSTRACT γδ T cells usually infiltrate many different types of cancer, but it is unclear
whether they inhibit or promote tumor progression. Moreover, properties of tumor-infiltrating …

[HTML][HTML] Diversity of tumor-infiltrating, γδ T-cell abundance in solid cancers

G Chabab, F Boissière-Michot, C Mollevi, J Ramos… - Cells, 2020 - mdpi.com
γδ T-cells contribute to the immune response against many tumor types through their direct
cytolytic functions and their capacity to recruit and regulate the biological functions of other …

Squamous cell tumors recruit γδ T cells producing either IL17 or IFNγ depending on the tumor stage

E Lo Presti, F Toia, S Oieni, S Buccheri, A Turdo… - Cancer Immunology …, 2017 - AACR
The identification of reciprocal interactions between tumor-infiltrating immune cells and the
microenviroment may help us understand mechanisms of tumor growth inhibition or …

[HTML][HTML] Pro-tumor γδ T cells in human cancer: polarization, mechanisms of action, and implications for therapy

G Chabab, C Barjon, N Bonnefoy, V Lafont - Frontiers in immunology, 2020 - frontiersin.org
The tumor immune microenvironment contributes to tumor initiation, progression and
response to therapy. Among the immune cell subsets that play a role in the tumor …

[HTML][HTML] Plasticity of γδ T cells: impact on the anti-tumor response

V Lafont, F Sanchez, E Laprevotte… - Frontiers in …, 2014 - frontiersin.org
The tumor immune microenvironment contributes to tumor initiation, progression, and
response to therapy. Among the immune cell subsets that play a role in the tumor …

[HTML][HTML] γδ T cells and tumor microenvironment: from immunosurveillance to tumor evasion

E Lo Presti, G Pizzolato, AM Corsale… - Frontiers in …, 2018 - frontiersin.org
γδ T cells possess cytotoxic antitumor activity mediated by production of proinflammatory
cytokines, direct cytotoxic activity, and regulation of the biological functions of other cell …

[HTML][HTML] Tumor-infiltrating γδ T lymphocytes: pathogenic role, clinical significance, and differential programing in the tumor microenvironment

E Lo Presti, F Dieli, S Meraviglia - Frontiers in immunology, 2014 - frontiersin.org
There is increasing clinical evidence indicating that the immune system may either promote
or inhibit tumor progression. Several studies have demonstrated that tumors undergoing …

Gut γδ T cells as guardians, disruptors, and instigators of cancer

T Suzuki, L Hayman, A Kilbey, J Edwards… - Immunological …, 2020 - Wiley Online Library
Colorectal cancer is the third most common cancer worldwide with nearly 2 million cases per
year. Immune cells and inflammation are a critical component of colorectal cancer …

γδ T cells in cancer: a small population of lymphocytes with big implications

M Raverdeau, SP Cunningham… - Clinical & …, 2019 - Wiley Online Library
Abstract γδ T cells are a small population of mostly tissue‐resident lymphocytes, with both
innate and adaptive properties. These unique features make them particularly attractive …

[PDF][PDF] Heterogeneity of human γδ T cells and their role in cancer immunity

HW Lee, YS Chung, TJ Kim - Immune Network, 2020 - synapse.koreamed.org
The γδ T cells are unconventional lymphocytes that function in both innate and adaptive
immune responses against various intracellular and infectious stresses. The γδ T cells can …