Phosphorus MRS was evaluated as a monitor of tumour therapeutic response to the herpes
simplex virus thymidine kinase suicide gene therapy paradigm. In vivo 31P spectra were …

Magnetic resonance imaging and in vivo localized H magnetic resonance spectroscopy
were used to evaluate a gene therapy approach for treating experimental brain tumors. This …

Using a rat C6 brain tumor model, we studied the antitumor effects of Herpes simplex virus
type 1 thymidine kinase (HSV-tk) gene transfer followed by ganciclovir treatment. C6 glioma …

Programmed cell death was induced by HSV-tk gene therapy in rat BT4C glioma cells, and
metabolite changes associated with cell damage were monitored in vivo by 1 H NMR …

We have used high resolution magnetic resonance imaging to monitor malignant rat BT4C
gliomas in vivo following herpes simplex virus thymidine kinase gene and ganciclovir (GCV) …

Hyperpolarised [1‐13C] pyruvate MRI has shown promise in monitoring therapeutic efficacy
in a number of cancers including glioma. In this study, we assessed the pyruvate response …

Perfusion, hypoxia and nucleoside uptake during ganciclovir therapy were determined in a
murine HSV-1 TK-expressing tumour model (KBALB-STK). HSV-1 TK mRNA transcription in …

Contradictory experimental results and human trials have questioned the clinical relevance
of the HSVtk/ganciclovir system. To bypass the problem of transfection efficiency, we used a …

Brain tumors are a major cause of morbidity and mortality in the population. New primary
brain tumors develop in 2–4 of 100,000 adults each year [1]. Recent evidence indicates that …

We have investigated the effects of thymidine kinase-mediated gene therapy in a malignant
rat BT4C glioma by using 1H nuclear magnetic resonance spectroscopy in vivo. Ganciclovir …