Preclinical evaluation of the penciclovir analog 9-(4-[18F] fluoro-3-hydroxymethylbutyl) guanine for in vivo measurement of suicide gene expression with PET
MM Alauddin, A Shahinian, EM Gordon… - Journal of Nuclear …, 2001 - Soc Nuclear Med
The gene for herpes simplex virus thymidine kinase (HSV-tk) is widely used as a suicide
gene in experimental gene therapy of cancer. 9-(4-Fluoro-3-hydroxymethylbutyl) guanine …
gene in experimental gene therapy of cancer. 9-(4-Fluoro-3-hydroxymethylbutyl) guanine …
[PDF][PDF] 1H magnetic resonance spectroscopic imaging of phospholipase activity in rat gliomas in vivo
T Liimatainen, A Erkkilä, O Gröhn… - Proc. Intl. Soc. Mag …, 1747 - researchgate.net
Materials and methods: HSV-thymidine kinase-positive BT4C gliomas (n= 4) were
inoculated intracranially in BDIX rats, and treated with ganciclovir (GCV) as described before …
inoculated intracranially in BDIX rats, and treated with ganciclovir (GCV) as described before …
The thymidine kinase/ganciclovir-mediated “suicide” effect is variable in different tumor cells
C Beck, S Cayeux, SD Lupton, B Dörken… - Human gene …, 1995 - liebertpub.com
The herpes simplex virus thymidine kinase (HSV-TK) converts ganciclovir (GCV) into a toxic
product and allows selective elimination of TK+ cells in vitro and in vivo. It is currently being …
product and allows selective elimination of TK+ cells in vitro and in vivo. It is currently being …
Development and application of quantitative real time PCR and RT-PCR assays that discriminate between the full-length and truncated herpes simplex virus thymidine …
SB Ebeling, HPE Borst, ER Simonetti, S Hol… - Journal of virological …, 2003 - Elsevier
Allogeneic donor T lymphocytes manipulated genetically to express the herpes simplex
virus thymidine kinase (HSV-TK) gene have emerged as promising tools to alter the balance …
virus thymidine kinase (HSV-TK) gene have emerged as promising tools to alter the balance …
Enhanced tumor cell killing in the presence of ganciclovir by herpes simplex virus type 1 vector-directed coexpression of human tumor necrosis factor-α and herpes …
S Moriuchi, T Oligino, D Krisky, P Marconi, D Fink… - Cancer research, 1998 - AACR
Past studies have documented the promise of herpes simplex virus type 1 (HSV-1)
thymidine kinase (TK) suicide gene therapy as a potential antitumor treatment. HSV-TK …
thymidine kinase (TK) suicide gene therapy as a potential antitumor treatment. HSV-TK …
Superior Cytotoxicity with Ganciclovir Compared with Acyclovir and 1-β-d-Arabinofuranosylthymine in Herpes Simplex Virus-Thymidine Kinase-expressing Cells: A …
LZ Rubsam, BL Davidson, DS Shewach - Cancer research, 1998 - AACR
Enzyme-prodrug therapy using ganciclovir and herpes simplex virus-thymidine kinase (HSV-
TK) has demonstrated excellent antitumor activity in many different types of malignant cells …
TK) has demonstrated excellent antitumor activity in many different types of malignant cells …
Synergistic enhancement of herpes simplex virus thymidine kinase/ganciclovir-mediated cytotoxicity by hydroxyurea
PD Boucher, LJ Ostruszka, DS Shewach - Cancer research, 2000 - AACR
We have previously demonstrated (LZ Rubsam et al., Cancer Res., 59: 669–675, 1999) that
low ganciclovir (GCV) triphosphate (TP) levels similar to cellular deoxynucleotide …
low ganciclovir (GCV) triphosphate (TP) levels similar to cellular deoxynucleotide …
[PDF][PDF] Multitracer studies during gene therapy of hepatoma cells with herpes simplex virus thymidine kinase and ganciclovir
U Haberkorn, A Altmann, I Morr… - Journal of Nuclear …, 1997 - Soc Nuclear Med
Methods: Morris hepatoma cells were transfected with a retroviral vector bearing the HSVtk
gene, and different clones were estab lished by selection with the neomycin analog G418 …
gene, and different clones were estab lished by selection with the neomycin analog G418 …
Longitudinal evaluation of the metabolic response of a tumor xenograft model to single fraction radiation therapy using magnetic resonance spectroscopy
AG Tessier, A Yahya, MP Larocque… - Physics in Medicine …, 2014 - iopscience.iop.org
Proton magnetic resonance spectroscopy (MRS) was used to evaluate the metabolic profile
of human glioblastoma multiform brain tumors grown as xenografts in nude mice before, and …
of human glioblastoma multiform brain tumors grown as xenografts in nude mice before, and …
High resolution proton nuclear magnetic resonance (1H NMR) spectroscopy of surviving C6 glioma cells after X-ray irradiation
Ł Matulewicz, A Cichoń, M Sokół… - Folia …, 2013 - termedia.pl
Purpose: To study biochemical response of living model of glioma to X-rays irradiation using
high resolution proton nuclear magnetic resonance (1 H NMR) spectroscopy. Material and …
high resolution proton nuclear magnetic resonance (1 H NMR) spectroscopy. Material and …