Assessment of suicide enzyme activity would have considerable impact on the planning and
the individualization of suicide gene therapy of malignant tumors. This may be done by …

The therapeutic combination of the herpesvirus simplex virus type 1 (HSV-1) thymidine
kinase (TK) gene and the prodrug, ganciclovir (GCV), has found great utility for the treatment …

Abstract The injectable anaesthetics Hypnorm/Hypnovel, chloral hydrate and etomidate,
were examined for their effects on C3H/He mouse core temperature and on the in vivo 31P …

Transfer of the herpes simplex virus type-1 thymidine kinase (HSV-tk) gene into tumor cells
followed by ganciclovir (GCV) administration, will provide selective tumor cell killing. We …

We are developing procedures to repeatedly and noninvasively ¡ magethe expression of
transplanted reporter genes in living ani mals and in patients, using PET. We have …

Abstract [C-11]-2'-Fluoro-5-methyl-1-beta-D-arabinofuranosyluracil ([C-11] FMAU) and [F-18]-
9-[(3-fluoro-1-hydroxy-2-propoxy) methyl] guanine ([F-18] FHPG), radiolabeled …

Human glioma cell lines 8-MG-BA and 42-MG-B A were infected with retrovirus vector
containing the herpes simplex virus thymidine kinase (HSV/A:) gene. The effect of acyclovir …

Purpose: The antiviral nucleoside analogue ganciclovir is a potent inhibitor of replication in
herpes viruses and is effective against cytomegalovirus infections in immunocompromised …

Cancer suicide gene therapy affords the prospect of using the most optimal genes available
because the source of the therapeutic gene is often irrelevant. Currently, there are numerous …

Ganciclovir (GCV) is widely used as a prodrug for selective activation in tumor cells
expressing herpes simplex virus thymidine kinase (HSV-TK) because of its ability to induce …