Transient cervical nerve root compression modulates pain: load thresholds for allodynia and sustained changes in spinal neuropeptide expression
RD Hubbard, Z Chen, BA Winkelstein - Journal of biomechanics, 2008 - Elsevier
Nerve root compression produces chronic pain and altered spinal neuropeptide expression.
This study utilized controlled transient loading in a rat model of painful cervical nerve root …
This study utilized controlled transient loading in a rat model of painful cervical nerve root …
Transient cervical nerve root compression in the rat induces bilateral forepaw allodynia and spinal glial activation: mechanical factors in painful neck injuries
RD Hubbard, BA Winkelstein - Spine, 2005 - journals.lww.com
Study Design. An in vivo rat model of transient cervical nerve root compression. Objectives.
To investigate the potential for cervical nerve root compression to produce behavioral …
To investigate the potential for cervical nerve root compression to produce behavioral …
The role of graded nerve root compression on axonal damage, neuropeptide changes, and pain-related behaviors
Rapid neck motions can load cervical nerve roots and produce persistent pain. This study
investigated the cellular basis of radicular pain and mechanical implications of tissue …
investigated the cellular basis of radicular pain and mechanical implications of tissue …
Spinal Neuropeptide Responses in Persistent and Transient Pain Following Cervical Nerve Root Injury:(Presented at the 2004 CSRS Meeting)
SM Rothman, RA Kreider, BA Winkelstein - Spine, 2005 - journals.lww.com
Study Design. Behavioral and immunohistochemical analysis in rat models of persistent and
transient allodynia. Objectives. To examine separate cervical nerve root injuries …
transient allodynia. Objectives. To examine separate cervical nerve root injuries …
The roles of mechanical compression and chemical irritation in regulating spinal neuronal signaling in painful cervical nerve root injury
S Zhang, KJ Nicholson, JR Smith, TM Gilliland, PP Syré… - 2013 - sae.org
Both traumatic and slow-onset disc herniation can directly compress and/or chemically
irritate cervical nerve roots, and both types of root injury elicit pain in animal models of …
irritate cervical nerve roots, and both types of root injury elicit pain in animal models of …
Cytokine antagonism reduces pain and modulates spinal astrocytic reactivity after cervical nerve root compression
SM Rothman, BA Winkelstein - Annals of biomedical engineering, 2010 - Springer
Relationships between nerve root compression, behavioral sensitivity, spinal cytokines, and
glial reactivity are not fully defined for painful cervical nerve root compression. Spinal …
glial reactivity are not fully defined for painful cervical nerve root compression. Spinal …
Time-dependent mechanics and measures of glial activation and behavioral sensitivity in a rodent model of radiculopathy
SM Rothman, KJ Nicholson… - Journal of Neurotrauma, 2010 - liebertpub.com
Nerve root compression induces persistent behavioral hypersensitivity and spinal glial
reactivity. Viscoelastic properties of neural tissues suggest that physiologic outcomes may …
reactivity. Viscoelastic properties of neural tissues suggest that physiologic outcomes may …
Development of a duration threshold for modulating evoked neuronal responses after nerve root compression injury
KJ Nicholson, JC Quindlen, BA Winkelstein - 2011 - sae.org
Cervical nerve roots are susceptible to compression injuries of various durations. The
duration of an applied compression has been shown to contribute to both the onset of …
duration of an applied compression has been shown to contribute to both the onset of …
Quantification of neural tissue injury in a rat radiculopathy model: comparison of local deformation, behavioral outcomes, and spinal cytokine mRNA for two surgeons
BA Winkelstein, MD Rutkowski, JN Weinstein… - Journal of neuroscience …, 2001 - Elsevier
Clinical and experimental work indicate that a variety of factors contribute to radicular pain
mechanisms, including mechanical injury. While it has been qualitatively suggested that the …
mechanisms, including mechanical injury. While it has been qualitatively suggested that the …
Mechanical thresholds for initiation and persistence of pain following nerve root injury: mechanical and chemical contributions at injury
BA Winkelstein, JA DeLeo - J. Biomech. Eng., 2004 - asmedigitalcollection.asme.org
There is much evidence supporting the hypothesis that magnitude of nerve root mechanical
injury affects the nature of the physiological responses which can contribute to pain in …
injury affects the nature of the physiological responses which can contribute to pain in …