CD47, a cell surface protein known for inhibiting phagocytosis, plays a critical role in the
tumor microenvironment (TME) and is a potential biomarker for cancer. However, directly …

Alveolar and interstitial macrophages play crucial roles in eradicating pathogens and
transformed cells in the lungs. The immune checkpoint CD47, found on normal and …

Accumulating evidence indicates that a small subset of cancer cells, termed the tumor-
initiating cells or cancer stem cells (CSCs), construct a reservoir of self-sustaining cancer …

Tumor cells can evade attack by phagocytes by upregulating the self-marker CD47. The
mechanisms underlying tumor CD47 upregulation, however, remain unclear. Here, we …

Simple Summary Lung cancer is the leading cause of cancer-related death worldwide.
Despite treatment advances, high rates of tumor recurrence emphasize the need for new …

Small-cell lung cancer (SCLC) is a highly aggressive subtype of lung cancer with limited
treatment options. CD47 is a cell-surface molecule that promotes immune evasion by …

CD47 is a widely expressed cell-surface protein that regulates phagocytosis mediated by
cells of the innate immune system, such as macrophages and dendritic cells. CD47 serves …

Macrophages as components of the innate immune system play a critical role in antitumor
responses. Strategies for targeting CD47 are becoming a hot spot for cancer therapy. The …

Overexpression of CD47 is frequently observed in various types of human malignancies,
inhibiting myeloid-mediated elimination of tumor cells and affecting the prognosis of cancer …

CD47 is a widely expressed cell surface protein that functions as a regulator of phagocytosis
mediated by cells of the innate immune system, such as macrophages and dendritic cells …