Despite that burnout presents a serious burden for modern society, there are no diagnostic
criteria. Additional difficulty is the differential diagnosis with depression. Consequently, there …

Epigenetic modifications in response to traumatic experience and stress are emerging as
important factors in the long-term biological trajectories leading to stress-related psychiatric …

As one of the most common psychiatric disorders, depression has been a major public
health problem. Growing evidence suggests that epigenetic modification is essential in …

There has been a limited number of systematic reviews conducted to summarize the
overview of the relationship between DNA methylation and depression, and to critically …

Objective DNA methylation has been associated with both early life stress and depression.
This study examined the combined association of DNA methylation at multiple CpG probes …

Epigenetic mechanisms play a role in the detrimental effects of traumatic stress and the
development of post-traumatic stress disorder (PTSD). However, it is unknown whether …

Susceptibility and resilience to mental disorders result from a complex choreography of
gene–environment interactions with epigenetics at the intersection of external psychological …

Importance Depressive disorders arise from a combination of genetic and environmental risk
factors. Epigenetic disruption provides a plausible mechanism through which gene …

Stress plays an important role in major depressive disorder (MDD) and is one of the state
dependent factors in suicidal behavior. A dysfunctional hypothalamic-pituitary-adrenal axis …

Objectives Anxiety is associated with elevated levels of the inflammatory cytokine interleukin-
6 (IL-6) and an increased risk for diseases with an inflammatory aetiology. In cancer, higher …