Marfan syndrome (MFS) is a genetic disorder that results in accelerated aortic root widening
and aneurysm. However, management of MFS patients with blood pressure (BP)‐lowering …

Marfan syndrome (MFS) is a genetic disorder that frequently leads to aortic root dissection
and aneurysm. Despite promising preclinical and pilot clinical data, a recent large-scale …

Objective To assess the tolerability and efficacy of the investigational use of the angiotensin
II receptor blocker losartan added to β-blockade (BB) to prevent progressive aortic root …

The Marfan syndrome (MFS) patients are highly predisposed to thoracic aortic aneurysm
and/or dissection, with virtually every patient having evidence of aortic disease at some point …

Aortic root dilatation and dissection is the leading cause of death in Marfan syndrome (MFS).
We previously showed that excessive TGFβ-dependent activation of ERK signaling drives …

Importance Thoracic aortic aneurysms leading to acute aortic dissections are a major cause
of morbidity and mortality despite significant advances in surgical treatment, which remains …

Abstract Aim Patients with Marfan syndrome have an increased risk of life-threatening aortic
complications, mostly preceded by aortic dilatation. Treatment with losartan, an angiotensin …

Introduction The role of losartan in preventing aortic root dilatation in Marfan syndrome has
been evaluated in many clinical trials; however, the results are conflicting. Methods We …

Background Recently, we demonstrated that losartan reduced the aortic root dilatation rate
(AoDR) in adults with Marfan syndrome (MFS); however, responsiveness was diverse. The …

Mallat and Daugherty Losartan in Marfan Syndrome e11 would definitely validate the
superiority of losartan compared with atenolol in providing aortic protection through …