Endogenous myocardial nitric oxide (NO) may modulate the transition from adaptive to
maladaptive hypertrophy leading to heart failure. This review summarizes the information on …

The roles of nitric oxide (NO) in the heart have been studied intensely ever since the first
report nearly 2 decades ago showing that endogenous NO modulates cardiac myocyte …

The role of nitric oxide (NO) as a regulator of cardiac contraction was suggested in the early
nineties, but a consensual view of its main functions in cardiac physiology has only recently …

Endogenous myocardial nitric oxide (NO) may modulate the transition from adaptive to
maladaptive remodeling leading to heart failure. In rodent models of pressure overload or …

Nitric oxide (NO) produced in the heart by nitric oxide synthase (NOS) is a highly reactive
signaling molecule and an important modulator of myocardial function. NOS catalyzes the …

The different cell types comprising cardiac muscle express one or more of the three isoforms
(neuronal NOS, or nNOS; inducible NOS, or iNOS; and endothelial NOS, or eNOS) of nitric …

Recognition of significance of nitric oxide synthases (NOS) in cardiovascular regulations has
led to intensive research and development of therapies focused on NOS as potential …

Nitric oxide, which is produced endogenously within cardiac myocytes by three distinct
isoforms of nitric oxide synthase, is a key regulator of myocardial function. This review will …

Significance: The regulation of myocardial function by constitutive nitric oxide synthases
(NOS) is important for the maintenance of myocardial Ca2+ homeostasis, relaxation and …

Nitric oxide (NO) has essential roles in heart physiology, including the regulation of
myocardial contractility and coronary blood flow, and in heart pathophysiology, particularly …