The hypothalamus is one of the master regulators of various physiological processes,
including energy balance and nutrient metabolism. These regulatory functions are mediated …

Diet-induced obesity leads to devastating and common chronic diseases, fueling ongoing
interest in determining new mechanisms underlying both obesity and its consequences. It is …

Determining the effect of hypothalamic inflammatory signals on energy balance presents a
paradox. On the one hand, a large body of work has identified inflammatory signaling in the …

The control of energy homeostasis relies on robust neuronal circuits that regulate food
intake and energy expenditure. Although the physiology of these circuits is well understood …

Preclinical studies have suggested that chronic inflammation in the brain might be
associated with multiple metabolic disorders, including obesity and diabetes. In particular …

Over the last years, hypothalamic inflammation has been linked to the development and
progression of obesity and its sequelae. There is accumulating evidence that this …

Interdisciplinary studies in the research fields of endocrinology and immunology show that
obesity-associated overnutrition leads to neuroinflammatory molecular changes, in …

The hypothalamus is a key brain region in the regulation of energy balance as it controls
food intake and both energy storage and expenditure through integration of humoral, neural …

The hypothalamus is a crucial organ for the maintenance of appropriate body fat storage.
Neurons in the hypothalamic arcuate nucleus (ARH) detect energy shortage or surplus via …

When challenged with a variety of inflammatory threats, multiple systems across the body
undergo physiological responses to promote defense and survival. The constellation of …