Carboxylesterases (CESs, EC 3.1. 1.1) constitute a large class of enzymes that determine
the therapeutic efficacy and toxicity of ester/amide drugs. Without exceptions, all mammalian …

Carboxylesterases (CES) are a well recognized, yet incompletely characterized family of
proteins that catalyze neutral lipid hydrolysis. Some CES have well-defined roles in …

Nuclear receptors and transcription factors regulate the mRNA expression of many drug
metabolizing enzymes, including the carboxylesterases (Ces). However, there are few data …

Importance of the field: Emerging evidence demonstrates that several nuclear receptor (NR)
family members regulate drug-inducible expression and activity of several important …

Mammalian carboxylesterases (CEs) are key enzymes from the serine hydrolase
superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) …

Background: Carboxylesterases (CES) play a critical role in catalyzing hydrolysis of esters,
amides, carbamates and thioesters, as well as bioconverting prodrugs and soft drugs. The …

Carboxylesterases (CES, EC 3.1. 1.1) hydrolyze ester, amide, and carbamate bonds found
in xenobiotics and endobiotics. Multiple CES genes exist in mammals with evidence of …

Mammalian carboxylesterases are key serine hydrolases that catalyze the hydrolysis of a
wide variety of ester compounds in the corresponding carboxylic acids and alcohols. In …

Carboxylesterases (CE) are ubiquitous enzymes found in both human and animal tissues
and are responsible for the metabolism of xenobiotics. This includes numerous natural …

Carboxylesterases belong to Phase I group of drug metabolizing enzymes. They hydrolyze a
variety of drug esters, amides, carbamates and similar structures. There are five …