Vegfc/d-dependent regulation of the lymphatic vasculature during cardiac regeneration is influenced by injury context
CJ Vivien, C Pichol-Thievend, CB Sim… - Npj Regenerative …, 2019 - nature.com
The lymphatic vasculature mediates essential physiological functions including fluid
homeostasis, lipid and hormone transport, and immune cell trafficking. Recent studies have …
homeostasis, lipid and hormone transport, and immune cell trafficking. Recent studies have …
Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration
D Gancz, BC Raftrey, G Perlmoter, R Marín-Juez… - Elife, 2019 - elifesciences.org
In recent years, there has been increasing interest in the role of lymphatics in organ repair
and regeneration, due to their importance in immune surveillance and fluid homeostasis …
and regeneration, due to their importance in immune surveillance and fluid homeostasis …
Late developing cardiac lymphatic vasculature supports adult zebrafish heart function and regeneration
MRM Harrison, X Feng, G Mo, A Aguayo, J Villafuerte… - Elife, 2019 - elifesciences.org
The cardiac lymphatic vascular system and its potentially critical functions in heart patients
have been largely underappreciated, in part due to a lack of experimentally accessible …
have been largely underappreciated, in part due to a lack of experimentally accessible …
The evolving cardiac lymphatic vasculature in development, repair and regeneration
K Klaourakis, JM Vieira, PR Riley - Nature Reviews Cardiology, 2021 - nature.com
The lymphatic vasculature has an essential role in maintaining normal fluid balance in
tissues and modulating the inflammatory response to injury or pathogens. Disruption of …
tissues and modulating the inflammatory response to injury or pathogens. Disruption of …
Impact of lymphangiogenesis on cardiac remodeling after ischemia and reperfusion injury
Y Shimizu, R Polavarapu, KL Eskla… - Journal of the …, 2018 - Am Heart Assoc
Background Lymphatic vessels interconnect with blood vessels to form an elaborate system
that aids in the control of tissue pressure and edema formation. Although the lymphatic …
that aids in the control of tissue pressure and edema formation. Although the lymphatic …
Lymphatic and immune cell cross-talk regulates cardiac recovery after experimental myocardial infarction
Objective: Lymphatics play an essential pathophysiological role in promoting fluid and
immune cell tissue clearance. Conversely, immune cells may influence lymphatic function …
immune cell tissue clearance. Conversely, immune cells may influence lymphatic function …
The lymphatic system in zebrafish heart development, regeneration and disease modeling
X Feng, S Travisano, CA Pearson, CL Lien… - Journal of …, 2021 - mdpi.com
Heart disease remains the single largest cause of death in developed countries, and novel
therapeutic interventions are desperately needed to alleviate this growing burden. The …
therapeutic interventions are desperately needed to alleviate this growing burden. The …
Formation and growth of cardiac lymphatics during embryonic development, heart regeneration, and disease
D Gancz, G Perlmoter, K Yaniv - Cold Spring Harbor …, 2020 - cshperspectives.cshlp.org
The lymphatic system plays crucial roles in regulating fluid homeostasis, immune
surveillance, and lipid transport. As is in most of the body's organs, the heart possesses an …
surveillance, and lipid transport. As is in most of the body's organs, the heart possesses an …
Genetic blockade of lymphangiogenesis does not impair cardiac function after myocardial infarction
TCS Keller, L Lim, SV Shewale… - The Journal of …, 2021 - Am Soc Clin Investig
In recent decades, treatments for myocardial infarction (MI), such as stem and progenitor cell
therapy, have attracted considerable scientific and clinical attention but failed to improve …
therapy, have attracted considerable scientific and clinical attention but failed to improve …
The cardiac lymphatic system stimulates resolution of inflammation following myocardial infarction
JM Vieira, S Norman, CV Del Campo… - The Journal of …, 2018 - Am Soc Clin Investig
Myocardial infarction (MI) arising from obstruction of the coronary circulation engenders
massive cardiomyocyte loss and replacement by non-contractile scar tissue, leading to …
massive cardiomyocyte loss and replacement by non-contractile scar tissue, leading to …