Allergen immunotherapy enhances the immunosuppressive effects of Treg cells to alleviate allergic rhinitis by decreasing PU-1+ Treg cell numbers

YL Qiao, WE Jiao, S Xu, YG Kong, YQ Deng… - International …, 2022 - Elsevier
Objective To investigate the role of Tregs and their subtypes in the treatment of allergic
rhinitis with allergen immunotherapy (AIT) as well as the underlying mechanism. Methods 1 …

[HTML][HTML] Gene expression pattern of Treg and TCR Vγ subfamily T cells before and after specific immunotherapy in allergic rhinitis

R Zheng, X Wu, X Huang, Y Chen, Q Yang, Y Li… - Journal of translational …, 2014 - Springer
Background T regulatory cell (Treg) plays a critical role in respiratory allergy and allergen-
specific immunotherapy (SIT), and γδ T cells might participate in mediating Treg quantity …

[HTML][HTML] CD8+ Tregs ameliorate inflammatory reactions in a murine model of allergic rhinitis

L Lin, F Dai, J Wei, Z Chen - Allergy, Asthma & Clinical Immunology, 2021 - Springer
Abstract Background CD8+ CD25+ fork-head box transcription factor (Foxp3)+ regulatory T
cells (CD8+ Tregs) play a role in immune tolerance. However, the role of these cells in …

Influences of CD8+ Tregs on Peripheral Blood Mononuclear Cells from Allergic Rhinitis Patients

L Lin, F Dai, J Wei, Z Chen - The Laryngoscope, 2021 - Wiley Online Library
Objectives CD8+ (or CD4+) CD25+ fork‐head box transcription factor (Foxp3)+ regulatory T
cells (CD8+ or CD4+ Tregs) all play a significant role in immune homeostasis and tolerance …

The role of Treg cell subsets in allergic disease

T Boonpiyathad, ZC Sözener, M Akdis… - Asian Pacific journal of …, 2020 - zora.uzh.ch
Allergic diseases are caused by a hypersensitivity reaction to an external substance that is
normally not harmful to the body. An imbalance between type 2 immune response and …

[HTML][HTML] Changes in CD4+ CD25+ FoxP3+ regulatory T cells and serum cytokines in sublingual and subcutaneous immunotherapy in allergic rhinitis with or without …

M Xian, M Feng, Y Dong, N Wei, Q Su… - International Archives of …, 2020 - karger.com
Background: Few studies have directly compared the immunologic responses to specific
subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT). Objective: We …

Specific immunotherapy and turning off the T cell: how does it work?

C Ozdemir, UC Kucuksezer, M Akdis… - Annals of Allergy, Asthma & …, 2011 - Elsevier
OBJECTIVE: To examine T-regulatory (Treg) cell functions in allergic immune responses
and their roles during allergen specific immunotherapy based on recent developments and …

Modulation of regulatory T cells by intranasal allergen immunotherapy in an experimental rat model of airway allergy

S Moitra, A Datta, S Mondal, I Hazra, SMO Faruk… - International …, 2017 - Elsevier
Allergic airway diseases such as asthma and allergic rhinitis are increasing in prevalence
worldwide. The theory of an altered Th1/Th2 balance in allergic diathesis has recently been …

[PDF][PDF] Effects of allergen-specific immunotherapy on functions of helper and regulatory T cells in patients with seasonal allergic rhinitis

C Kirmaz, OO Kirgiz, P Bayrak, O Yilmaz… - European Cytokine …, 2011 - academia.edu
Background. Seasonal allergic rhinitis (SAR) is characterized by a helper T (Th) 2 cell-
mediated immune response at the target site. There is a relative Th1 and/or regulatory T …

Role of regulatory T cells in airway inflammation in asthma

T Kawayama, T Kinoshita, K Matsunaga… - The Kurume medical …, 2017 - jstage.jst.go.jp
Asthma is an allergic disease characterized by chronic airway inflammation, airway
hyperresponsiveness (AHR), reversibility and remodeling. Inhaled corticosteroids (ICS) are …