[HTML][HTML] HIV-1 Vpr loads uracil DNA glycosylase-2 onto DCAF1, a substrate recognition subunit of a cullin 4A-ring E3 ubiquitin ligase for proteasome-dependent …
J Ahn, T Vu, Z Novince, J Guerrero-Santoro… - Journal of biological …, 2010 - ASBMB
The human immunodeficiency virus type 1 (HIV-1) accessory protein, Vpr, interacts with
several host cellular proteins including uracil DNA glycosylase-2 (UNG2) and a cullin-RING …
several host cellular proteins including uracil DNA glycosylase-2 (UNG2) and a cullin-RING …
Human Immunodeficiency Virus Type 1 Vpr Contains Two Leucine-Rich Helices That Mediate Glucocorticoid Receptor Coactivation Independently of Its Effects on G2 …
MP Sherman, CMC de Noronha, D Pearce… - Journal of …, 2000 - Am Soc Microbiol
Human immunodeficiency virus type 1 (HIV-1) Vpr participates in nuclear targeting of the
viral preintegration complex in nondividing cells and induces G2 cell cycle arrest in …
viral preintegration complex in nondividing cells and induces G2 cell cycle arrest in …
Increased Levels of Wee-1 Kinase in G2 Are Necessary for Vpr- and Gamma Irradiation-Induced G2 Arrest
H Yuan, M Kamata, YM Xie, ISY Chen - Journal of virology, 2004 - Am Soc Microbiol
Human immunodeficiency virus type 1 (HIV-1) Vpr induces cell cycle arrest at the G2/M
transition and subsequently apoptosis. Here we examined the potential involvement of Wee …
transition and subsequently apoptosis. Here we examined the potential involvement of Wee …
Heat shock protein 70 protects cells from cell cycle arrest and apoptosis induced by human immunodeficiency virus type 1 viral protein R
S Iordanskiy, Y Zhao, L Dubrovsky… - Journal of …, 2004 - Am Soc Microbiol
Viral protein R (Vpr) of human immunodeficiency virus type 1 (HIV-1) is an accessory protein
that plays an important role in viral pathogenesis. This pathogenic activity of Vpr is related in …
that plays an important role in viral pathogenesis. This pathogenic activity of Vpr is related in …
[PDF][PDF] HIV-1, Vpr and the cell cycle
M Emerman - Current Biology, 1996 - cell.com
The human immunodeficiency virus 1 (HIV-1) is a complex retrovirus with more genes than
most retroviruses. One of these extra genes codes for a protein called Vpr, which has …
most retroviruses. One of these extra genes codes for a protein called Vpr, which has …
Induction of apoptosis by the Vpr protein of human immunodeficiency virus type 1 occurs independently of G2 arrest of the cell cycle
M Nishizawa, M Kamata, T Mojin, Y Nakai, Y Aida - Virology, 2000 - Elsevier
The HIV-1 accessory gene product Vpr can inhibit cell proliferation via cell cycle arrest at the
G2 phase, and it can induce apoptosis after G2 arrest. We found recently that C81, a carboxy …
G2 phase, and it can induce apoptosis after G2 arrest. We found recently that C81, a carboxy …
HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes
Human immunodeficiency virus type 1 (HIV-1) Vpr is a 15-kDa accessory protein that
contributes to several steps in the viral replication cycle and promotes virus-associated …
contributes to several steps in the viral replication cycle and promotes virus-associated …
[HTML][HTML] Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing
N Laguette, C Brégnard, P Hue, J Basbous, A Yatim… - Cell, 2014 - cell.com
The HIV auxiliary protein Vpr potently blocks the cell cycle at the G2/M transition. Here, we
show that G2/M arrest results from untimely activation of the structure-specific endonuclease …
show that G2/M arrest results from untimely activation of the structure-specific endonuclease …
Cytoplasmic retention of HIV-1 regulatory protein Vpr by protein-protein interaction with a novel human cytoplasmic protein VprBP
S Zhang, Y Feng, O Narayan, LJ Zhao - Gene, 2001 - Elsevier
Vpr is an HIV-1 auxiliary regulatory protein packaged in the virion. It has been shown to
enhance the nuclear transport of the HIV-1 pre-integration complex, activate transcription of …
enhance the nuclear transport of the HIV-1 pre-integration complex, activate transcription of …
[HTML][HTML] ATR and GADD45α mediate HIV-1 Vpr-induced apoptosis
JL Andersen, ES Zimmerman, JL DeHart… - Cell Death & …, 2005 - nature.com
The human immunodeficiency virus type-1 (HIV-1) accessory gene vpr encodes a
conserved 96-amino-acid protein that is necessary and sufficient for the HIV-1-induced block …
conserved 96-amino-acid protein that is necessary and sufficient for the HIV-1-induced block …