Vitamin A is required for male fertility and normal spermatogenesis. Retinoic acid (RA), an
active metabolite of vitamin A, is necessary for spermatogonial maturation and proper entry …

Knowledge of the regulation of testicular retinoic acid synthesis is crucial for understanding
its role in spermatogenesis. Bisdichloroacetyldiamines strongly inhibit spermatogenesis. We …

Germ cells in the mouse embryo can develop as oocytes or spermatogonia, depending on
molecular cues that have not been identified. We found that retinoic acid, produced by …

Retinoic acid (RA) plays a critical role in normal development, growth, and maintenance of
certain tissues. The action of RA is thought to be mediated in part by the three nuclear …

During mouse fetal development, meiosis is initiated in female germ cells only, with male
germ cells undergoing mitotic arrest. Retinoic acid (RA) is degraded by Cyp26b1 in the …

Retinoic acid (RA) induces spermatogonial differentiation, but the mechanism by which it
operates remains largely unknown. We developed a germ cell culture assay system to study …

BACKGROUND: All-trans retinoic acid (RA), the oxidative metabolite of vitamin A, is
essential for normal development. In addition, high levels of RA are teratogenic in many …

▪ Abstract Retinoic acid (RA) is involved in vertebrate morphogenesis, growth, cellular
differentiation, and tissue homeostasis. The use of in vitro systems initially led to the …

Although oral contraceptives have been available to women since the 1960s, contraceptive
options for men have remained limited. Spermatogenesis relies on the active metabolite of …

The active metabolite of vitamin A, retinoic acid (RA), is known to be essential for
spermatogenesis. Changes to RA levels within the seminiferous epithelium can alter the …