G protein-coupled receptors (GPCRs) are transmembrane receptor proteins that allow the
transfer of signals across the cell membrane. In addition to their physiological role, GPCRs …

G protein-coupled receptors (GPCRs) are transmembrane receptor proteins that trigger
numerous intracellular signaling pathways in response to the extracellular stimuli. The …

G protein-coupled receptors (GPCRs) play important roles in inflammation. Inflammatory
cells such as polymorphonuclear leukocytes (PMN), monocytes and macrophages express …

Rheumatoid arthritis (RA) is a chronic inflammatory disease that leads to joint damage and
even disability. Although there are various clinical therapies for RA, some patients still have …

G protein-coupled receptors (GPCRs) comprise the largest and most diverse family of
integral membrane proteins that participate in different physiological processes such as the …

G protein-coupled receptors (GPCRs) play important roles in human physiology. GPCRs are
involved in immunoregulation including regulation of the inflammatory response …

Many extracellular stimuli, such as neurotransmitters, hormones, chemokines, proteinases,
inflammatory mediators, odorants, and light, are recognized by the superfamily of G protein …

Introduction G protein-coupled receptors (GPCRs) are transmembrane receptor proteins,
which allow the transfer of signals across the membrane. Rheumatoid arthritis (RA) is an …

Objective Previous work has suggested that the granulocyte macrophage colony stimulating
factor (GM-CSF)–GM-CSF receptor α axis (GM-CSFRα) may provide a new therapeutic …

Osteoarthritis (OA) is the most common chronic joint disease characterized, for which there
are no available therapies being able to modify the progression of OA and prevent long-term …