Hybrid drugs as potential combatants against drug-resistant microbes: a review

HA Saadeh, MS Mubarak - Current topics in medicinal …, 2017 - ingentaconnect.com
Antimicrobial resistance to drugs is a serious threat to public health. Different strategies have
been adopted to deal with antimicrobial resistance to known drugs, one such strategy is the …

Transition Towards Antibiotic Hybrid Vehicles: The Next Generation Antibacterials

R Kuppusamy, K Browne, D Suresh… - Current Medicinal …, 2023 - ingentaconnect.com
Antibiotic resistance is a growing global health problem when the discovery and
development of novel antibiotics are diminishing. Various strategies have been proposed to …

Bifunctional antibiotic hybrids: A review of clinical candidates

AJJ Koh, V Thombare, M Hussein, GG Rao… - Frontiers in …, 2023 - frontiersin.org
Antibiotic resistance is a top threat to human health and a priority across the globe. This
problematic issue is accompanied by the decline of new antibiotics in the pipeline over the …

Combination of drugs: An effective approach for enhancing the efficacy of antibiotics to combat drug resistance

MSA Khan - Antibacterial Drug Discovery to Combat MDR: Natural …, 2019 - Springer
Currently available antibiotics have been effective in treating infectious diseases; however,
the development of resistance to these drugs has led to the emergence of new and the re …

Dual-acting hybrid antibiotics: a promising strategy to combat bacterial resistance

V Pokrovskaya, T Baasov - Expert opinion on drug discovery, 2010 - Taylor & Francis
Importance of the field: The emerging and sustained resistance to currently available
antibiotics and the poor pipeline of new antibacterials urgently call for the development of …

Development and research progress of anti-drug resistant bacteria drugs

X Cui, Y Lü, C Yue - Infection and drug resistance, 2021 - Taylor & Francis
Bacterial resistance has become increasingly serious because of the widespread use and
abuse of antibiotics. In particular, the emergence of multidrug-resistant bacteria has posed a …

Drug combinations: a strategy to extend the life of antibiotics in the 21st century

M Tyers, GD Wright - Nature Reviews Microbiology, 2019 - nature.com
Antimicrobial resistance threatens a resurgence of life-threatening bacterial infections and
the potential demise of many aspects of modern medicine. Despite intensive drug discovery …

Combination therapy as a strategy to control infections caused by multi-resistant bacteria: current review

P Hernandez-Rodriguez, LP Baquero - Current Drug Targets, 2022 - ingentaconnect.com
Antimicrobial Resistance (AMR) is one of the main challenges of today's medicine because
it has become a global problem that affects the treatment of multiple infections and impacts …

[HTML][HTML] Drug repurposing for next-generation combination therapies against multidrug-resistant bacteria

Y Liu, Z Tong, J Shi, R Li, M Upton, Z Wang - Theranostics, 2021 - ncbi.nlm.nih.gov
Antimicrobial resistance has been a global health challenge that threatens our ability to
control and treat life-threatening bacterial infections. Despite ongoing efforts to identify new …

Hybrid molecules development: A versatile landscape for the control of antifungal drug resistance: A review

CG Anusionwu, BA Aderibigbe… - Mini Reviews in …, 2019 - ingentaconnect.com
Hybrid molecule approach of drug design has become popular due to advantages such as
delayed resistance, reduced toxicity, ease of treatment of co-infection and lower cost of …