The necroptosis cell death pathway has been implicated in host defense and in the
pathology of inflammatory diseases. While phosphorylation of the necroptotic effector …

Necroptosis is a form of caspase-independent programmed cell death that arises from
disruption of cell membranes by the mixed lineage kinase domain-like (MLKL) …

Mixed lineage kinase domain-like (MLKL) is a component of the" necrosome," the
multiprotein complex that triggers tumor necrosis factor (TNF)-induced cell death by …

Necroptosis is considered to be complementary to the classical caspase-dependent
programmed cell death pathway, apoptosis. The pseudokinase Mixed Lineage Kinase …

Necroptosis is a lytic programmed cell death pathway with origins in innate immunity that is
frequently dysregulated in inflammatory diseases. The terminal effector of the pathway …

The pseudokinase, MLKL (mixed-lineage kinase domain-like), is the most terminal
obligatory component of the necroptosis cell death pathway known. Phosphorylation of the …

Recent data from two independent laboratories have shed new light on the molecular
mechanisms by which mixed lineage kinase domainlike (MLKL) promotes a peculiar form of …

The recent implication of the cell death pathway, necroptosis, in innate immunity and a
range of human pathologies has led to intense interest in the underlying molecular …

Necroptosis (or 'programmed necrosis') is a caspase‐independent cell death pathway that
operates downstream of death receptors, including Tumour Necrosis Factor Receptor‐1 …

Several programmed lytic and necrotic-like cell death mechanisms have now been
uncovered, including the recently described receptor interacting protein kinase-3 (RIPK3) …