Complexity of danger: the diverse nature of damage-associated molecular patterns

L Schaefer - Journal of Biological Chemistry, 2014 - ASBMB
In reply to internal or external danger stimuli, the body orchestrates an inflammatory
response. The endogenous triggers of this process are the damage-associated molecular …

DAMPs from cell death to new life

E Vénéreau, C Ceriotti, ME Bianchi - Frontiers in immunology, 2015 - frontiersin.org
Our body handles tissue damage by activating the immune system in response to
intracellular molecules released by injured tissues [damage-associated molecular patterns …

DAMPs activating innate immune responses in sepsis

JW Kang, SJ Kim, HI Cho, SM Lee - Ageing research reviews, 2015 - Elsevier
Sepsis refers to the deleterious and non-resolving systemic inflammatory response of the
host to microbial infection and is the leading cause of death in intensive care units. The …

DAMPs and DAMP-sensing receptors in inflammation and diseases

M Ma, W Jiang, R Zhou - Immunity, 2024 - cell.com
Damage-associated molecular patterns (DAMPs) are endogenous danger molecules
produced in cellular damage or stress, and they can activate the innate immune system …

DAMP-sensing receptors in sterile inflammation and inflammatory diseases

T Gong, L Liu, W Jiang, R Zhou - Nature Reviews Immunology, 2020 - nature.com
The innate immune system has the capacity to detect 'non-self'molecules derived from
pathogens, known as pathogen-associated molecular patterns, via pattern recognition …

Damage-associated molecular patterns and the systemic immune consequences of severe thermal injury

PB Comish, D Carlson, R Kang… - The journal of immunology, 2020 - journals.aai.org
Thermal injury is often associated with a proinflammatory state resulting in serious
complications. After a burn, the innate immune system is activated with subsequent immune …

Dendritic cells and damage-associated molecular patterns: endogenous danger signals linking innate and adaptive immunity

G Nace, J Evankovich, R Eid, A Tsung - Journal of innate immunity, 2011 - karger.com
Dendritic cells (DCs) are potent antigen-presenting cells critical in regulating the adaptive
immune response. The role of DCs is dichotomous; they may both present antigens and the …

Danger signals in trauma

B Relja, K Mörs, I Marzi - European journal of trauma and emergency …, 2018 - Springer
This review summarizes a short list of currently discussed trauma-induced danger-
associated molecular patterns (DAMP). Due to the bivalent character and often pleiotropic …

Release mechanisms of major DAMPs

A Murao, M Aziz, H Wang, M Brenner, P Wang - Apoptosis, 2021 - Springer
Damage-associated molecular patterns (DAMPs) are endogenous molecules which foment
inflammation and are associated with disorders in sepsis and cancer. Thus, therapeutically …

[HTML][HTML] The role of damage-associated molecular patterns (DAMPs) in human diseases: part II: DAMPs as diagnostics, prognostics and therapeutics in clinical …

WG Land - Sultan Qaboos University Medical Journal, 2015 - ncbi.nlm.nih.gov
This article is the second part of a review that addresses the role of damage-associated
molecular patterns (DAMPs) in human diseases by presenting examples of traumatic …