[HTML][HTML] Artesunate: the best drug in the treatment of severe and complicated malaria

Q Li, P Weina - Pharmaceuticals, 2010 - mdpi.com
This review summarizes progress in treating severe and complicated malaria, which are
global problems, claiming at least one million lives annually, and have been accompanied …

Artemisinin drugs: novel antimalarial agents

RN Price - Expert Opinion on Investigational Drugs, 2000 - Taylor & Francis
Artemisinin and its derivatives, artesunate and artemether, represent a new class of
antimicrobial drug with potent activity against Plasmodium falciparum. Although they show …

Clinical pharmacology and therapeutic potential of artemisinin and its derivatives in the treatment of malaria

PJ de Vries, TK Dien - Drugs, 1996 - Springer
Artemisinin and its derivatives are renowned for their potent antimalarial activity. They have
found their way into clinical use in many areas where malaria is endemic. The in vitro …

Artesunate: a review of its pharmacology and therapeutic efficacy in the treatment of malaria

LB Barradell, A Fitton - Drugs, 1995 - Springer
Synopsis Artesunate is an antimalarial agent, available in oral, rectal and parenteral
formulations, that provides a rapid clinical effect in patients with Plasmodium falciparum …

[HTML][HTML] Review of the clinical pharmacokinetics of artesunate and its active metabolite dihydroartemisinin following intravenous, intramuscular, oral or rectal …

CA Morris, S Duparc, I Borghini-Fuhrer, D Jung… - Malaria journal, 2011 - Springer
Artesunate (AS) is a clinically versatile artemisinin derivative utilized for the treatment of mild
to severe malaria infection. Given the therapeutic significance of AS and the necessity of …

Artemisinin drugs in the treatment of malaria: from medicinal herb to registered medication

MA Van Agtmael, TA Eggelte, CJ Van Boxtel - Trends in pharmacological …, 1999 - cell.com
Registration in Europe of several artemisinin drugs for the treatment of malaria can soon be
expected. Artemisinin is isolated from the herb Artemisia annua, in use in China more than …

Formulation and pharmacokinetics of artemisinin and its derivatives

HAC Titulaer, J Zuidema, CB Lugt - International journal of pharmaceutics, 1991 - Elsevier
Artemisinin, the leading compound of a completely deviant class of drugs, might be of
incredible importance in the combat of malaria. Although the herb from which it is isolated …

[HTML][HTML] Recent advances in the therapeutic efficacy of artesunate

N Ruwizhi, RB Maseko, BA Aderibigbe - Pharmaceutics, 2022 - mdpi.com
Artesunate, a semisynthetic artemisinin derivative, is well-known and used as the first-line
drug for treating malaria. Apart from treating malaria, artesunate has also been found to …

Pharmacokinetics and pharmacodynamics of intravenous artesunate in severe falciparum malaria

TME Davis, HL Phuong, KF Ilett, NC Hung… - Antimicrobial agents …, 2001 - Am Soc Microbiol
To provide novel data relating to the dispositions, effects, and toxicities of the artemisinin
derivatives in severe malaria, we studied 30 Vietnamese adults with slide-positive …

Pharmacokinetics of artemisinin-type compounds

V Navaratnam, S Mahsufi Mansor, NW Sit… - Clinical …, 2000 - Springer
Various compounds of the artemisinin family are currently used for the treatment of patients
with malaria worldwide. They are characterised by a short half-life and feature the most …