The late addition of core lipids to nascent apolipoprotein B100, resulting in the assembly and secretion of triglyceride-rich lipoproteins, is independent of both …

M Pan, J Liang, EA Fisher, HN Ginsberg - Journal of Biological Chemistry, 2002 - ASBMB
Although microsomal triglyceride transfer protein (MTP) and newly synthesized triglyceride
(TG) are critical for co-translational targeting of apolipoprotein B (apoB100) to lipoprotein …

Inhibition of the microsomal triglyceride transfer protein blocks the first step of apolipoprotein B lipoprotein assembly but not the addition of bulk core lipids in the …

DA Gordon, H Jamil, RE Gregg, SO Olofsson… - Journal of Biological …, 1996 - ASBMB
The microsomal triglyceride transfer protein (MTP) is required for assembly and secretion of
the lipoproteins containing apolipoprotein B (apoB): very low density lipoproteins and …

Microsomal triglyceride transfer protein activity is not required for the initiation of apolipoprotein B-containing lipoprotein assembly in McA-RH7777 cells

N Dashti, M Manchekar, Y Liu, Z Sun… - Journal of Biological …, 2007 - ASBMB
We previously demonstrated that the N-terminal 1000 amino acid residues of human
apolipoprotein (apo) B (designated apoB: 1000) are competent to fold into a three-sided …

The microsomal triglyceride transfer protein facilitates assembly and secretion of apolipoprotein B-containing lipoproteins and decreases cotranslational degradation …

S Wang, RS McLeod, DA Gordon, Z Yao - Journal of Biological Chemistry, 1996 - ASBMB
We studied the role of microsomal triglyceride transfer protein (MTP) in the synthesis,
secretion, and cotranslational degradation of apolipoprotein (apo) B using nonhepatic COS …

The microsomal triglyceride transfer protein catalyzes the post-translational assembly of apolipoprotein B-100 very low density lipoprotein in McA-RH7777 cells

S Rustaeus, P Stillemark, K Lindberg, D Gordon… - Journal of Biological …, 1998 - ASBMB
In cells in which the lipoprotein assembly process had been inactivated by brefeldin A (BFA),
membrane-associated apoB-100 disappeared without forming lipoproteins or being …

Normal activity of microsomal triglyceride transfer protein is required for the oleate-induced secretion of very low density lipoproteins containing apolipoprotein B from …

Y Wang, RS McLeod, Z Yao - Journal of Biological Chemistry, 1997 - ASBMB
The requirement of the activity of microsomal triglyceride transfer protein (MTP) for very low
density lipoprotein (VLDL) secretion was determined using McA-RH7777 cells stably …

Progress towards understanding the role of microsomal triglyceride transfer protein in apolipoprotein-B lipoprotein assembly

DA Gordon, H Jamil - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2000 - Elsevier
The microsomal triglyceride transfer protein (MTP) is necessary for the proper assembly of
the apolipoprotein B containing lipoproteins, very low density lipoprotein and chylomicrons …

Secretion of apolipoprotein B-containing lipoproteins from HeLa cells is dependent on expression of the microsomal triglyceride transfer protein and is regulated by …

DA Gordon, H Jamil, D Sharp… - Proceedings of the …, 1994 - National Acad Sciences
To elucidate the role of the microsomal triglyceride transfer protein (MTP) in lipoprotein
assembly, MTP and apolipoprotein B-53 (apoB 53; the N-terminal 53% of apoB) were …

Microsomal triacylglycerol transfer protein is required for lumenal accretion of triacylglycerol not associated with ApoB, as well as for ApoB lipidation

A Kulinski, S Rustaeus, JE Vance - Journal of Biological Chemistry, 2002 - ASBMB
The assembly of very low density lipoproteins in hepatocytes requires the microsomal
triacylglycerol transfer protein (MTP). This microsomal lumenal protein transfers lipids …

Microsomal triglyceride transfer protein is essential for hepatic secretion of apoB-100 and apoB-48 but not triglyceride

TY Hui, LM Olivier, S Kang, RA Davis - Journal of lipid research, 2002 - ASBMB
Despite a complete lack of microsomal triglyceride transfer protein (MTP), L35 rat hepatoma
cells secrete triglyceride-containing lipoproteins, albeit at a rate 25% of that of parental FAO …