Production of therapeutic quantities of 64Cu using a 12 MeV cyclotron

A Obata, S Kasamatsu, DW McCarthy, MJ Welch… - Nuclear medicine and …, 2003 - Elsevier
64Cu is a useful radiotracer for positron emission tomography (PET) and a promising
radiotherapy agent for the treatment of cancer. Recently, 64Cu-labeled …

Efficient production of high specific activity 64Cu using a biomedical cyclotron

DW McCarthy, RE Shefer, RE Klinkowstein… - Nuclear medicine and …, 1997 - Elsevier
Copper-64 (T 1 2= 12.7 h) is an intermediate-lived positron-emitting radionuclide that is a
useful radiotracer for positron emission tomography (PET) as well as a promising …

High purity production and potential applications of copper-60 and copper-61

DW McCarthy, LA Bass, PD Cutler, RE Shefer… - Nuclear medicine and …, 1999 - Elsevier
Previously we described the high yield production of 64Cu using a target system designed
specifically for low energy, biomedical cyclotrons. In this study, the use of this target system …

A feasibility study of the therapeutic application of a mixture of 67/64Cu radioisotopes produced by cyclotrons with proton irradiation

L De Nardo, G Pupillo, L Mou, J Esposito… - Medical …, 2022 - Wiley Online Library
Abstract Purpose 64Cu and 67Cu radioisotopes have nuclear characteristics suitable for
nuclear medicine applications. The production of 64Cu is already well established …

Efficient preparation of high-quality 64Cu for routine use

T Ohya, K Nagatsu, H Suzuki, M Fukada… - Nuclear Medicine and …, 2016 - Elsevier
Introduction Copper-64 is an attractive radionuclide for positron emission tomography and is
emerging as a radiotherapeutic agent. The demand of 64 Cu with low metallic impurities has …

An improved 62Zn/62Cu generator based on a cation exchanger and its fully remote-controlled preparation for clinical use

T Fukumura, K Okada, H Suzuki, R Nakao… - Nuclear medicine and …, 2006 - Elsevier
OBJECTIVE: The goal of this study was to develop an improved 62Zn/62Cu generator based
on cation exchange resin and remote preparation at high radioactivity scale for clinical use …

Production of no‐carrier‐added 64Cu from zinc metal irradiated under boron shielding

KR Zinn, TR Chaudhuri, TP Cheng, J Steven Morris… - Cancer, 1994 - Wiley Online Library
Background. Positron emission tomography offers advantages for radioimmunodiagnosis of
cancer but requires radionuclides of appropriate half‐life that have high specific activity and …

Production of no-carrier-added 64 Cu and applications to molecular imaging by PET and PETIS as a biomedical tracer

SH Watanabe, Y Iida, N Suzui, T Katabuchi… - … of radioanalytical and …, 2009 - akjournals.com
Copper-64 was produced by the 64 Ni (p, n) 64 Cu reaction using enriched 64 NiO target.
We investigated and compared the production yield of 64 Cu for proton beams of various …

A simple Cu-64 production and its application of Cu-64 ATSM

JY Kim, H Park, JC Lee, KM Kim, KC Lee, HJ Ha… - Applied Radiation and …, 2009 - Elsevier
One of the positron emission radionuclides, 64Cu, has been reported to be a particularly
effective radioisotope in PET imaging study. This utility of 64Cu depends on the chemical …

[HTML][HTML] Alternative routes for 64Cu production using an 18 MeV medical cyclotron in view of theranostic applications

G Dellepiane, P Casolaro, I Mateu, P Scampoli… - Applied Radiation and …, 2023 - Elsevier
Radiometals play a fundamental role in the development of personalized nuclear medicine.
In particular, copper radioisotopes are attracting increasing interest since they offer a varying …