OBJECTIVE: To elucidate events that initiate the involvement and stimulation of fibroblasts in
systemic sclerosis (SSc). METHODS: We examined 15 patients with SSc diffuse form, 15 …

OBJECTIVE:. To investigate the in vitro effect of granulocyte macrophage-colony stimulating
factor (GM-CSF) on the deposition of extracellular matrix (ECM) in fibroblasts obtained from …

In this report we investigate the behaviour of the serum levels of Granulocyte Macrophage
Colony Stimulating Factor (GM-CSF) in the course of Systemic Sclerosis (SS). This cytokine …

OBJECTIVE:. Systemic sclerosis (SSc) is characterized by excessive production of collagen
and other components of the extracellular matrix (ECM) by fibroblasts. The ECM receptors …

In the present study the effects of Granulocyte-Macrophage Colony Stimulating Factor
(GMCSF) on fibroblast growth and activity have been studied. In this regard the AA have …

Granulocyte-macrophage colony-stimulating factor (GM-CSF), a product of activated T
lymphocytes, macrophages, endothelial cells, fibroblasts, and keratinocytes, is thought to …

Fibroblasts are involved in all pathologies characterized by increased ExtraCellularMatrix
synthesis, from wound healing to fibrosis. Granulocyte Macrophage-Colony Stimulating …

Skin hyperpigmentation and itching are characteristic findings in systemic sclerosis (SSC)
patients. Stem cell factor (SCF, c-kit ligand) is a multifunctional cytokine which can promote …

Objective The pathophysiology of systemic sclerosis (SSc) is poorly understood, but recent
studies indicate the involvement of cytokines in the functional changes of SSc fibroblasts …

Objectives: To verify the effectiveness of G-CSF in the treatment of non-healing skin lesions
in SSc patients. Methods: 26 SSc patients (23 F and 3 M, age 54±13, 6 yrs) with skin ulcers …