Preclinical studies demonstrate that generalized endothelial cell dysfunction and
microvascular impairment are potentially reversible causes of age-related vascular cognitive …

Exercise is associated with higher cognitive function and is a promising intervention to
reduce the risk of dementia. With advancing age, there are changes in the vasculature that …

Cerebrovascular dysfunction is a critical risk factor for the pathogenesis of Alzheimer's
disease (AD). The purinergic P2Y2 receptor and endoplasmic reticulum (ER) stress are …

Functional status is considered the main determinant of healthy aging. Impairment in
skeletal muscle and the cardiovascular system, two interrelated systems, results in …

Introduction Mental stress has been identified as a trigger of cardiovascular events. A single
episode of stress can induce acute impairments in endothelial function in healthy adults …

Background Endothelial dysfunction associated with hypercholesterolemia is an early event
in atherosclerosis characterized by redox imbalance associated with high superoxide …

Arterial hypertension (AH) is a major cause of cardiovascular diseases (CVD), leading to
dysfunction of many organs, including the heart, blood vessels and kidneys. AH is a …

Obesity is a serious medical condition, defined as excessive accumulation of fat. Abdominal
fat is recognized as the major risk for obesity related diseases such as: hypertension …

Loneliness and social isolation are common sources of chronic stress in modern society.
Epidemiological studies have demonstrated that loneliness and social isolation increase …

Alzheimer disease and cerebrovascular dementia are two common causes of dementia and,
by present diagnostic criteria, are mutually exclusive using vascular pathology as an …