OBJECTIVE We have determined the frequency of specific mutations in the RET proto‐
oncogene in sporadic medullary thyroid carcinomas (MTCs) and correlated the presence or …

The hereditary multiple endocrine neoplasia syndromes types 2A and B (MEN 2A and B)
were recently linked to germline mutations in the RET proto-oncogene, altering one of five …

Abstract Analysis of peripheral blood or tumor DNA samples from 101 patients with apparent
sporadic medullary thyroid carcinoma (MTC) was performed to assess the frequency of RET …

The frequency and prognostic relevance of RET proto-oncogene somatic mutations in
sporadic medullary thyroid carcinoma (MTC) remain controversial. In order to study somatic …

Germline point mutations in exons 10, 11, and 16 of the ret protooncogene have been
identified as causative in multiple endocrine neoplasia type 2 and in familial medullary …

Sixty-one heterozygotes harboring the germline V804L mutation of the RET protooncogene
were identified in five independent families. A total of 31 subjects underwent surgery …

Mutations in the RET proto-oncogene are associated with the pathogenesis of medullary
thyroid carcinoma (MTC). In an attempt to understand this process, we examined …

Germ-like and somatic mutations in the RET proto-oncogene are associated with inherited
and sporadic medullary thyroid carcinoma (MTC). The majority of patients with multiple …

Summary BACKGROUND AND OBJECTIVES Medullary thyroid carcinoma (MTC) occurs
both sporadically and In the autosomal domlnantly inherited multiple endocrine neoplasia …

The RET protooncogene mutations responsible for multiple endocrine neoplasia type 2 are
inherited as autosomic dominant traits. We describe here a novel germline homozygous …