Purpose: Recent studies have reported high frequencies of somatic mutations in the
phosphoinositide-3-kinase catalytic α (PIK3CA) gene in several human solid tumors …

Abstract Phosphatidylinositol 3-kinases (PI3Ks) are heterodimeric lipid kinases that regulate
cellular activities such as proliferation, survival, motility and morphology. Recent studies …

We previously reported 4 PIK3CA mutations in 38 head and neck cancer samples, 3 of
which were identified in 6 pharyngeal cancer samples. To determine the mutation frequency …

Dear Sir, By molecular cytogenetic studies, we have previously identified high frequency of
copy number gain or amplification on chromosomes 3q (70%) in nasopharyngeal carcinoma …

PIK3CA, which encodes the catalytic subunit, p110-alpha, of phosphatidylinositol 3-kinase
(PI3K), is implicated in the development and progression of numerous neoplasias including …

Phosphatidylinositol 3‐kinases (PI3K) are a group of heterodimeric lipid kinases that
regulate many cellular processes. Gene amplification and somatic mutations mainly within …

Alpelisib selectively inhibits the p110α catalytic subunit of PI3Kα and is approved for
treatment of breast cancers harboring canonical PIK3CA mutations. In head and neck …

Abstract The phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway is one of the most
commonly deregulated pathways in human cancers. PI3K comprises a catalytic (p110α) and …

A recent report revealed that phosphoinositide-3-kinase, catalytic, alpha (PIK3CA) gene is
somatically mutated in several types of human cancer, suggesting the mutated PIK3CA gene …

Mutation of PIK3CA, the gene coding for the p110α catalytic subunit of phosphoinositide 3‐
kinase (PI3K), has been reported in a limited range of human tumors. We now report that …