The ubiquitous toxic metalloid arsenic elicits pleiotropic adverse and adaptive responses in
mammalian species. The biological targets of arsenic are largely unknown at present. We …

The antioxidant response element (ARE) is known to regulate expression and induction of
NQO1, GST Ya, and other detoxifying enzyme genes in response to antioxidants and …

Antioxidant-response element (ARE) and nuclear factor Nrf2-mediated expression and
coordinated induction of genes encoding chemopreventive proteins, including NQO1, are …

The antioxidant response element (ARE) and transcription factor Nrf2 regulate basal
expression and antioxidant induction of NAD (P) H: quinone oxidoreductase-1 (NQO1) and …

NQO1 [NAD (P) H: quinone oxidoreductase 1] has an integral role in cellular responses to
oxidative stress. The expression of NQO1 is up-regulated in the mouse following challenge …

The antioxidant response element (ARE) and Nrf2 are known to regulate the expression and
coordinated induction of genes encoding detoxifying enzymes including NAD (P) H: quinone …

Contamination of drinking water by carcinogen arsenic (As) is of worldwide concern as its
exposure poses potential threat to human health. As such, it is important to understand the …

The antioxidant responsive element (ARE) is a cis-acting regulatory element located in the
5′-flanking region of several genes encoding phase II detoxification enzymes, including …

Arsenic is present in the environment and has become a worldwide health concern due to its
toxicity and carcinogenicity. However, the specific mechanism (s) by which arsenic elicits its …

Transcription factor NF-E2 p45-related factor 2 (Nrf2) mediates adaptation to oxidants and
electrophiles through up-regulating genes that contain antioxidant response elements …