Introduction Estrogen receptor (ER) β is predicted to play an important role in prevention of
breast cancer development and metastasis. We have shown previously that ERβ inhibits …

Estrogen receptor (ER) β is predicted to play an important role in the prevention of breast
cancer development and progression. We have previously shown that ERβ suppresses …

Previously, we showed that hypoxia induces ligand-independent estrogen receptor (ER) α
activation. In this study, we found that hypoxia activated the ERβ-mediated transcriptional …

The estrogen receptor (ER) plays an important role in breast cancer development and
progression. Hypoxia has been shown to modulate the level of ERα expression, which is …

A majority of breast cancers are driven by estrogen via estrogen receptor-α (ERα). Our
previous studies indicate that hypoxia-inducible factor 1α (HIF-1α) cooperates with ERα in …

Abstract Background About 75–80% of breast tumors express the estrogen receptor alpha
(ER-α) and are treated with endocrine-target therapeutics, making this the premier …

The involvement of estrogen (E2) and hypoxia in tumor progression is well established.
Hypoxia has been reported to activate and degrade estrogen receptor alpha (ERα) in breast …

The estrogen receptor is one of the most important transcription factors in breast tumor
growth and development. We, and others, have previously shown that hypoxia induces rapid …

In women breast cancer is still the most commonly diagnosed cancer. This type of cancer is
classified as a hormone-dependent tumor. Estrogen receptor (ER) expression and functional …

Under low oxygen conditions (hypoxia), cells activate survival mechanisms including
metabolic changes and angiogenesis, which are regulated by HIF-1. The estrogen-related …